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Biomedical Research
|
Volume 29
Page 43
allied
academies
CARDIOLOGY AND CARDIOVASCULAR MEDICINE
STEM CELLS AND REGENERATIVE MEDICINE
&
International Conference on
International Conference on
J u n e 1 8 - 1 9 , 2 0 1 8 | O s a k a , J a p a n
Joint Event on
CHANGES IN THE SYSTEMIC INFLAMMATORY RESPONSE AND
RENAL FILTRATION FUNCTIONS USING A CLOSED CIRCUIT
OF THE ARTIFICIAL CIRCULATION WITH CORONARY ARTERY
BYPASS GRAFTING
Damir B
National research cardiac surgery center, Kazakhstan
T
he objective of this report was to study the direct results of cardiopulmonary bypass surgery in conditions of
cardiopulmonary bypass in closed and open circuits.
Methods:
2 cohorts of patients underwent coronary artery bypass grafting using open and closed CPB contours. Patients
in group 1 (n = 50; mean age 65 ±4,2 years) underwent coronary artery bypass grafting in the closed CPB contour. Patients
in group 2 (n = 50; mean age 64 ±5,3years) underwent coronary artery bypass grafting in the open CPB contour. Clinical
characteristics of both cohorts were comparable. The total time of cardiopulmonary bypass was lower in the 1-st group
than in the 2-nd group (58min±12,7 and 64min ±16,9, respectively; p = 0,04). The average number of grafts was 3 ±0,67 in
the control group, 3 ±0,53 in the comparative group. Postoperative analysis of laboratory indicators has been divided into 2
stages at the time of six hours and sixteen hours.
Results:
When comparing two groups on the expiration of 6 hours after operation level of leucocytes, platelets, C-reactive
protein, urea and creatinine has not undergone a significant difference. After 16 hours of operation, the level of leucocytes
was 10х109 ±13,2 and 11,3х109 ±2,4 (p= 0,02) respectively; the level of C-reactive protein was 4mg/dl ±2,8 and 5,6 mg/
dl ±2,2 (p=0,01) respectively. There were no statistically significant changes in urea and creatinine levels in both groups.
Conclusion:
The closed contour of cardiopulmonary bypass can be used effectively and safe for coronary artery bypass
grafting surgery.
biktashevdamir@gmail.comBiomed Res 2018, Volume 29 | DOI: 10.4066/biomedicalresearch-C2-006