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N o v e m b e r 2 3 - 2 4 , 2 0 1 8 | B a n g k o k , T h a i l a n d
Joint Event on
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
YEARS
Pharma Summit 2018 & Gastro Summit 2018 Asian Journal of Biomedical and Pharmaceutical Sciences | ISSN: 2249-622X | Volume 8
&
GLOBAL PHARMA SUMMIT
GASTROENTEROLOGY AND HEPATOLOGY
2nd International Conference on
BM Gurupadayya et al., Asian J Biomed Pharmaceut Sci 2018, Volume 8 | DOI: 10.4066/2249-622X-C5-014
PHARMACOKINETIC DETERMINATION
ATENOLOL ENANTIOMER IN RABBIT
PLASMA BY REVERSE PHASE UFLC
TECHNIQUE
BM Gurupadayya and Charan Raju C
JSS Academy of Higher Education and Research, India
The present work describes the pharmacokinetic profile of (R)- and (S)-
Atenolol (ATL) enantiomer in rabbits using rapid and selective liquid chro-
matography with liquid-liquid extraction (LLE) method. The ATL enantiomers
were extracted from plasma by means of LLE using and were analyzed on a
Lux cellulose i5 segment (150×4.6 mm, 5µ) column with ultraviolet detection
at 225 nm. Atenolol enantiomers indicated great determination with a reten-
tion time (tR) of 2.7 min and 3.10 min individually. The lower limit of quantifi-
cation of the ATL enantiomers in plasma was 2 µg/ml. The validated method
was successfully applied to chiral pharmacokinetic studies of oral adminis-
tration of racemic ATL to rabbits. (S)-ATL showed almost similar AUC, Tmax,
and Cmax and same half-life compared (R)-ATL, indicating similar bioavail-
ability of the both isomer.
BM Gurupadayya working as the professor in the de-
partment of Pharmaceutical chemistry at JSS College
of Pharmacy, JSS Academy of Higher Education & Re-
search, Mysuru, India. The current area of his interest lies
in the field of bioanalytical method developments, chiral
drug analysis and drug and herbal drug interactions. He
has authored and co-authored over a hundred research
papers on pharmaceutical analysis and pharmaceutical
chemistry. He was awarded Dr PD Sethi Annual award’
for best research paper on application of TLC/HPTLC. I
have received several research grants from AICTE, UGC,
VGST and DST funding agencies. He has guided more
than 30 students in their master’s program and 7 PhD
degrees.
BIOGRAPHY