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N o v e m b e r 2 3 - 2 4 , 2 0 1 8 | B a n g k o k , T h a i l a n d
Joint Event on
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
YEARS
Pharma Summit 2018 & Gastro Summit 2018 Asian Journal of Biomedical and Pharmaceutical Sciences | ISSN: 2249-622X | Volume 8
&
GLOBAL PHARMA SUMMIT
GASTROENTEROLOGY AND HEPATOLOGY
2nd International Conference on
Pawar Vinod S et al., Asian J Biomed Pharmaceut Sci 2018, Volume 8 | DOI: 10.4066/2249-622X-C5-014
EVALUATION OF ADAPTOGENIC ACTIVITY
PROFILE OF G. LUCIDUM AND P. SENEGA
Pawar Vinod S1, Mahesh Rode1 and Shivakumar Hugar2
1SVPM’S College of Pharmacy, India
2BLDEA’s SSM College of Pharmacy and Research Centre, India
The present investigation has been undertaken to evaluate adaptogenic
and related properties of methanolic extracts of the G. lucidum and P. sen-
ega using various experimental animal models.
The graded doses of MEGL and MEPS were evaluated for adaptogenic activi-
ty using acute restraint stress (ARS) and chronic cold restraint stress (CCRS)
in adult albino rats of 150-200g. Withania somnifera was used as reference
standard.
In acute and chronic stress study, significant reversal of altered biochemi-
cal markers, organs weight and hematological parameters seen in treated
groups. Oxidative injury in rat brain exposed to stress was significantly at-
tenuated by the treatment of both test extracts at graded doses. Histological
studies evident that pretreatment of MEGL and MEPS prevented congestion,
ulceration, leucocytic infiltration, edema and necrosis in stomach. Test ex-
tracts significantly exhibited stress busting potential by reversing the altered
brain levels of NA, DA and 5-HT. Also MEGL and MEPS at graded doses sig-
nificantly reduced the number of writhes in chemical induced stress in mice.
It is concluded that Ganoderma lucidum and Polygala senega are strong
adaptogens of natural origin, mitigating physical, chemical, acute and chron-
ic stress induced alterations. These agents can be of therapeutic value for
various stress related disorders viz. gastric ulcer, hyperplycemia, oxidation,
depression etc. The observed adaptogenic effect might be due to prevention
of desensitization of peripheral and central components of HPA axis and also
due antioxidant activity.
Pawar Vinod S working as an Associate Professor in the
Department of Pharmacology, SVPM’s College of Phar-
macy, Malegaon (Bk), Baramati, affiliated to Savitribai
Phule Pune university, Pune, India. He has received PhD
degree from Jawaharlal Nehru Technological University
(JNTU), Hyderabad, India in the field of Pharmacology
in 2014. He is having 13 years of teaching experience in
Biotechnology, Pharmacology and Human Anatomy &
Physiology. His area of research lies in the field of pre-
clinical pharmacology, endocrinal pharmacology and
ethnopharmacology. Dr Pawar Vinod S had worked on
research projects funded by SPPU. He has several re-
search publications/presentations to date in national
and international journals/conferences of high profile.
He had received “Gold Medal” Award for best research
paper on “Adaptogenic (Antistress) Activity of Methano-
lic Extract of Ganoderma lucidum Against Physical and
Hypoxic Stress in Mice” International conference on Ad-
vancement in Health Sciences, organized by Masterskill
University College of Health Sciences, Port Dickson, Ma-
laysia. He is appointed as nominee of CECSEA, Ministry
of Environment, Forest & Climate Change, Govt of India.
He is a life member of Association of Pharmaceutical
Teachers of India (APTI) and Registered Pharmacist of
Maharashtra State Pharmacy council (MSPC), India.
BIOGRAPHY