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Journal of Pathology and Disease Biology | Volume 2

September 06-07, 2018 | Edinburgh, Scotland

Pathology and Surgical Pathology

International Conference on

Peripheral neuropathy and the role of nerve biopsy: A revisit

Sujata Chaturvedi

Institute of Human Behaviour and Allied Sciences, India

Background:

Nervebiopsyhasbeenwidelyusedto investigate

patients with peripheral neuropathy and in many centres

it is still a part of the diagnostic armamentarium. In this

study the histopathological spectrum of the nerve biopsies

received is being revisited to analyze the various clinical

and pathologic features and, also, to assess their relevance.

Materials and Methods:

Retrospective analysis of the data

retrieved was done for 74 cases of nerve biopsies.

Results:

On the basis of the data and histopathological

features, broad diagnoses were obtained in 52 cases;

further categorized into: biopsies being supportive

for patient management (including acute and chronic

axonopathies, demyelinating neuropathies) and biopsies

considered essential for patient management (including

vasculitic neuropathies, leprous neuropathies, hereditary

neuropathies and chronic inflammatory demyelinating

neuropathies). Nine nerve biopsies did not show any

abnormal histopathological features while thirteen nerve

biopsies were found to be inadequate for diagnosis,

both these groups were categorized as non-contributory.

Conclusion:

With advanced nerve conduction studies

available, nerve biopsy is losing its relevance. However,

in our experience, nerve biopsy did complement the

clinical findings and nerve conduction studies, with

which, a close correlation is required to make the

histopathology of nerve biopsy more relevant in terms

of guiding further specific work up and management.