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Page 37
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Journal of Pathology and Disease Biology | Volume 2
September 06-07, 2018 | Edinburgh, Scotland
Pathology and Surgical Pathology
International Conference on
Prevalence and factors associated with hydatidiform mole among patients undergoing uterine
evacuation at Mbarara regional referral hospital
Olivier Mulisya, Drucilla J Roberts, Elizabeth S, Elly A, Damaris L, Tusabe T, Mpiima D, Lugobe H, Ssemujju A, Masinda A, Twizerimana
H and Julius M
FEPSI, DR Congo
Objective: We sought to determine the prevalence of and
factors associated with hydatidiform molar gestations
amongst patients undergoing uterine evacuation at Mbarara
Regional Referral Hospital (MRRH) Mbarara, Uganda.
Methods: This was a Cross-sectional study carried out from
November 2016 to February 2017. All patients admitted for
uterine evacuation for non-viable pregnancy were included.
The study registered 181 patients. Data was collected on
socio-demographics, medical conditions, obstetrics and
gynecological factors. The evacuated tissue received a full
gross and histopathologic examination. Cases of pathologically
suspected complete hydatidiformmole were confirmed by p57
immunohistochemistry. Data was analyzed using STATA 13.
Results: ThePrevalenceofhydatidiformmolewas6.1%(11/181).
All detected moles were complete hydatidiform moles, there
werenodiagnosedpartial hydatidiformmoles. Clinical diagnosis
ofmolar pregnancywas suspected in 13 patients but only 69.2%
(9/13) were confirmed as molar pregnancies histologically. Two
cases were clinically unsuspected. Factors that had a significant
relationship with complete hydatidiform mole included
maternal age of 35 years and above (aOR 13.5; CI: 1.46-125.31;
p=0.00), gestational age beyond the first trimester at the time
of uterine evacuation (aOR 6.2; CI: 1.07-36.14; p=0.04) and
history of previous abortion (aOR 4.3; CI: 1.00-18.57; p=0.05).
Conclusion: The prevalence of complete hydatidiform mole
was high at 6.1%.
Associated risk factors included advanced maternal age (35
years and above), history of previous abortions, and gestational
age beyond the first trimester at the time of evacuations.
Recommendations: We recommend putting in place capacity
to do routine histopathological examination of all products of
conception especially those at high risk for a molar gestation
either by clinical suspicion or risk factors including advanced
maternal age, advanced gestational age, and history of previous
abortion because of high prevalence of complete mole. We
recommend a cohort study aimed to determine risk factors of
hydatidiform mole and to determine the outcome of patients
withhydatidiformmoleundergoinguterineevacuationatMRRH.
e:
Notes: