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academies
February 18-19, 2019 | Paris, France
Joint Event
Green Chemistry and Technology
8
th
World Congress on
International Conference on
Organic and Inorganic Chemistry
Journal of Industrial and Environmental Chemistry| Volume: 3
The endophytic fungus
Trametes hirsuta
as a novel alternative source of podophyllotoxin and related
aryl tetralin lignans
Vijeshwar Verma
Shri Mata vaishno Devi University, India
T
he aryl tetralin lignans are synthesized by Podophyllum
sps. and are in great demand worldwide due to their use in
synthesis of topoisomerase inhibitors. However, the sustained
production of these aryl tetralin lignans requires large-scale
harvesting from the natural environments, which has resulted
in the plant-endangered status. In viewof the difficulties in their
total chemical synthesis, cultivation and failure of metabolic
engineering approaches, there is aneed to search for alternative
sources of production of aryl tetralin lignans. We unequivocally
established the methodology for isolation, identification, and
characterization of a novel fungal endophyte (Trametes hirsuta)
that produces aryl tetralin lignans consistently as shown by
HPLC, LC–MS, LC/MS–MS and 1H NMR. The lignans produced
by the microorganism are biologically active, and exhibit
potent antioxidant, anticancer and radioprotective properties.
This strategy promises to improve the production of these
therapeutically important compounds at lower costs.
e:
Verma211@gmail.comJ Ind Environ Chem 2019, Volume 3
DOI: 10.4066/2591-7331-C1-009