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J Med Oncl Ther 2017 Volume 2 | Issue 3
International Conference on
Oncology and Cancer Therapeutics
October 30- November 01, 2017 | Chicago, USA
Chronic inflammatory mediators in progression of oral cancer
Shrihari
Krishna Devaraya College of Dental Sciences and Hospital, India
O
ral cancer is a major cause of mortality and morbidity
across theworld. Becauseof extensiveuseof carcinogenic
products such as tobacco, alcohol and some cases are due to
virusessuchashumanpapillomavirusinducedoro-pharyngeal
cancer. These carcinogens induce inflammatory changes
in the inflammatory microenvironment of oral mucosa.
chronic inflammatory mediators in tumor microenvironment
are innate and adaptive immune cells and their secreting
factors such as chemokine’s, cytokine’s, growth factors, and
proteolytic enzymes activates transcriptional factors (NF-KB,
STAT-3) expressed by immune cells and tumor cells promotes
malignant changes.
Speaker Biography
Shrihari is working in the Department of Oral Medicine and Radiology at Krishna
Devaraya College of Dental Sciences and Hospital, Bangalore, India. He has published
many papers in reputed journals.
e:
drshrihariomr@gmail.com