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J Med Oncl Ther 2017 Volume 2 | Issue 3
International Conference on
Oncology and Cancer Therapeutics
October 30- November 01, 2017 | Chicago, USA
Chronic inflammatory diseases, malignancies and nutritional intervention
Helieh S Oz
University of Kentucky, USA
Chronic inflammatory diseases including periodontitis,
hepatitis, pancreatitis, gastrointestinal complications
which can further lead to malignancies. Inflammation and
immune response are required for the tissue defense,
regeneration and healing process. Yet, exaggerated and
chronic inflammation can advance to life-long debilitation,
loss of tissue function andorgan failure. Despite themillennial
advancements in diagnostic technology and therapeutic
modalities, there remains no effective cure for patients
who suffer from inflammatory diseases and malignancies.
Therefore, over 40% of patients with inflammatory
complications seek some form of complementary and
alternative medical (CAM) agents as adjunct therapeutic
modalities, to alleviate symptoms and possibly to prevent
outcomes of inflammation, whether or not to consent
their clinicians. There is not sufficient scientific information
or international regulatory enforcements regarding the
most available CAM agents which some may interact with
patients’ current therapies with severe consequences.
One of the most investigated agents is Green tea and it
polyphenols (GrTP) with potent antioxidants effects. GrTP
have important roles in regulating vital signaling pathways
comprise transcription nuclear factor-kappa B mediated
I kappa B kinase complex pathways, programmed cell
death pathways like caspases and B-cell lymphoma-2
and production of cyclooxygenase. This presentation will
review inflammatory disease and malignancies and explore
mechanism of actions for protective effects of nutritional
interventions and some reported adverse effects as well as
some food safety applications.
Speaker Biography
Helieh S Oz has DVM and MS (U. IL); PhD (U. MN) and clinical translational research
certificate (U. KY Med Center). She is an active member of American Association
of Gastroenterology (AGA) and AGA Fellow (AGAF). She is a microbiologist with
expertise in inflammatory and infectious diseases, innate and mucosal Immunity,
drug discoveries, pathogenesis, and micronutrient. She was PI on different NIH and
NIH-NCCAM grants to investigate Chronic Inflammatory Diseases and nutritional
interventions. She has over 90 publications in the areas of chronic inflammatory
disorders (pancreatitis, hepatitis, colitis and periodontitis) and micronutrients. She
serves as the Lead editor for some specials issues and book Chapters.
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