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allied
academies
J Med Oncl Ther 2017 | Volume 2 Issue 4
Oncology and Biomarkers Summit
November 27-28, 2017 | Atlanta, USA
Annual Congress on
T
his study investigated the metabolic alterations in a rat
model of hepatic ischemia reperfusion injury (IRI) using
the combined
in vivo
hyperpolarized ¹³C MRS and intravoxel
incoherent motion (IVIM)-diffusion weighted imaging (DWI).
Hyperpolarized 13C MRS with IVIM-DWI was performed
on the liver of nine sham-operated control rats and nine
rats before and after hepatic IRI. The hepatic IRI-induced
rats showed significantly higher ratios of [1-13C] alanine/
pyruvate, [1-13C] alanine/total carbon, [1-13C] lactate/
pyruvate and [1-13C] lactate/total carbon compared with
both sham-operated controls and rats before IRI, whereas
[1-13C] pyruvate/total carbon ratio was decreased in
IRI-induced rats. In IVIM-DWI study, apparent diffusion
coefficient (ADC), perfusion fraction (f) and D values in rats
after hepatic IRI were significantly lower than those of rats
before IRI and sham-operated controls. The levels of [1-13C]
alanine and [1-13C] lactate was negatively correlated with
ADC, f and D values, whereas the level of [1-13C] pyruvate
was positively correlated with these values. The levels of
[1-13C] alanine, [1-13C] lactate and [1-13C] pyruvate in
conjunction with IVIM-DWI and serum enzyme levels will be
helpful to evaluate the hepatic IRI.
e:
gwjeong@jnu.ac.krMetabolic biomarker for hepatic ischemia in a rat model using ¹³C hyperpolarized 13CMR spectroscopy
Gwang-Woo Jeong
Chonnam National University Medical School, Korea