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J Med Oncl Ther 2017 | Volume 2 Issue 4
Oncology and Biomarkers Summit
November 27-28, 2017 | Atlanta, USA
Annual Congress on
Background & Aim: Lowering cholesterol with statin
therapy results in substantial reductions in cardiovascular
complications. Mild to moderate muscular symptoms occur
especially when the statins are administered at high doses.
Vitamin D deficiency is common in Saudi Arabia but also
worldwide and may cause muscle dysfunction and ache.
Previous observations in European populations showed
that rs2306283A>G, p.Asn130Asp and rs4149056T>C,
p.Val174Ala in solute carrier organic anion transporter 1B1
(SLCO1B1) gene encoding the organic transporter protein,
may be responsible for statin uptake and thus explain the
majority of statin associated symptoms. The aim of the
present study was first to reveal a possible effect of Vitamin
D (Vit D) status, rs2306283A>G and rs4149056T>C on muscle
related symptoms, most importantly muscle ache and
investigate possible interactions between Vit D status and
the above-mentioned variants.
Methods: 50 individuals of Arab origin diagnosed with
hypercholesterolemia (half of them with statin associated
muscle symptoms) were recruited from outpatient clinics
in Riyadh and underwent phenotypic data assessment
including serum markers (lipid profile, creatine kinase and
Vit D status). In addition, genomic DNA was extracted and
genotyped using hybridization probes on a LightCycler® 96
Instrument Roche.
Results: VitDstatuswasassociatedwithmuscleache(O.R=3.6,
P=0.03). However, for creatine kinase levels, rs2306283A>G
and rs4149056T>C we did not find associations. Interesting,
both rs2306283A>G and rs4149056T>C were interacting
with Vit D status to influence muscle ache (P=0.05 and
P=0.02 respectively). When stratified according to Vit D
status, rs4149056T>C showed a significant association with
muscle ache (P=0.05).
Conclusion: Our preliminary results show an involvement of
Vit D and rs4149056T>C of SLCO1B1 in statin induced muscle
ache. This result encourages us to increase our sample size
to confirm our findings.
e:
Association of Vitamin D level and SLCO1B1 gene polymorphisms; rs2306283A>G and rs4149056T>C,
with the risk of statin induced myopathy in Saudi Arabia
Rajaa Fakhoury
Beirut Arab University, Lebanon