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J Med Oncl Ther 2017 | Volume 2 Issue 4
Oncology and Biomarkers Summit
November 27-28, 2017 | Atlanta, USA
Annual Congress on
Objective:
The objective of this study was to investigate
the value of hs-TNT and NT-proBNP levels in predicting
the stratification and prognosis risk of patients with STEMI
undergoing percutaneous coronary intervention directly.
Method:
Eighty-six patients with STEMI were divided into
fourgroups according to hs-TNT and NT-proBNP levels.
Group A: TNT≤1 ng/L, BNP>1800 ng/L, 22 patients. Group
B: TNT≤1 ng/L, BNP≤1800 ng/L, 21 patients. Group C: TNT>1
ng / L, BNP>1800 ng/L, 24 patients. Group D: TNT>1 ng/L,
BNP≤1800 ng/L, 19 patients. Every group has carried out
Percutaneous Coronary Intervention (PCI) immediately
after admission into hospital and followed up for 30 days.
The cardiac death of patients in each group was compared
with hospitalization and within 30 days. The onset of MACE
(Major Advance Cardiovascular Events) within 30 days, the
changes of LVEF and left ventricular shortening (FS) about
emergency PCI treatment immediately after surgery 7 days
and 30 days should be collected.
Results:
One patient (1/22, 4.5%) was died in Group A, no
patient was died in Group B, 3 patients (3/24, 12.5%) was
died in Group C and 1 patient (1/19, 5.3%) was died in Group
D. 12 patients (12/22, 54.5%) were occurred MACE in Group
A, 1 patient (1/21, 4.8%) was in Group B, 19 patients (19/22,
86.4%) were in Group C and 4 patients (4/19, 21.2%) were
in Group D during hospitalization. 1 patients (1/21, 4.8%) in
were occurred MACE in Group A, 1 patient (1/21, 4.8%) was
in Group B, 8 patients (8/22, 36.4%) were in Group C and
3 patients (3/18, 16.7%) were in Group D and followed up
for 30 days. Compared with other groups, the level of LVEF
and FS were the lowest (46±0.10, 23.33±5.68, p=0 .001) after
the surgery immediately and the level of LVEF (0.09±0.09
(p=0.003), 0.09±0.08 (p=0.000)) within 7 days and 30 days
were significantly improved in Group A. The level of LVEF and
FS were the highest (60±0.08, 32.16±5.85, p=0.001) within
30 days in Group B, which was higher than after the surgery
immediately (0.05±0.06). The level of LVEF and FS were the
lowest (48±0.11, 24.41±5.13) within 30 days in Group C,
which were decreased significantly (-0.03±0.10, p=0.000)
after the surgery immediately. In Group D, the level of LVEF
and FS (55±0.07) were lower slightly within 30 days than
after surgery immediately.
Conclusion:
Cast aside the limit of different time when ultra-
window stable STEMI patients seek treatment. Based on the
level of hs-TNT and NT-proBNP risk stratification, both the
patients of low level of hs-TNT and NT-proBNP and low level
of hs-TNT and high level of NT-proBNP can benefit more from
emergency PCI treatment. The above situation was possible
to break the STEMI guidelines defined that the window
time of treatment in the emergency PCI. The concept and
strategies of the STEMI treatment should be optimized and
improve the prognosis of patients and the overall level of
STEMI treatment.
e:
yilaoyilao@126.comDiscussion on the value of combined hs-TnT and NT-proBNP with ultra-window stable of STEMI
patient’s risk of stratification and prognosis in direct percutaneous coronary intervention
Lao Yi
Sun Yat-sen University, China