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J Med Oncl Ther 2017 | Volume 2 Issue 4
Oncology and Biomarkers Summit
November 27-28, 2017 | Atlanta, USA
Annual Congress on
P
soriasis is a chronic inflammatory skin disease mediated
by the cells and molecules of both the innate and
adaptive immune systems that involves red elevated patches
and flaking silvery scales. Despite intensive research,
psoriasis pathogenesis remains unknown. Our purpose
was to study the role of nickel in psoriasis using microarray
gene expression data. The unexpected outcome from this
study was the role of metronidazole in the treatment of
psoriasis. Six psoriasis microarray assays were downloaded
from the GEO database. Statistical tests have been done on
both normalized and nonnormalized data. We used KEGG,
Reactome and Biosystems for pathway analysis and RGD
for gene-chemicals interactions. Nickel upregulates the top
upregulated genes in psoriasis including AKR1B10, IL36G,
SERPINB4, KYNU, SERPINB3, TCN1, DEFB4A, HPSE, PI3,
SPRR2C, SPRR3, VNN3 and several S100 family members
without downregulating any of those upregulated genes.
Nickel also downregulates the top downregulated genes
such as KRT77, ID4, BTC, CCL27, CHP2, IL37 and RORC without
upregulating any of those downregulated genes. The strongly
upregulated pathways included immune response, defense
response (e.g., amebiasis), cell cycle and metabolic pathways
and the top downregulated pathways included inflammatory
bowel disease, keratins, ErbB, Chemokine, cytokine and TGF-
beta pathways. Based on the best of our knowledge, this is
the first study that highlighted the role of nickel in psoriasis
pathogenesis using microarray gene expression data. The
significant and unique effect of nickel in upregulating the
upregulated genes and downregulating the downregulated
genes in psoriasis and a strong affinity between the imidazole
ring were an indication of a possible dramatic effect of
metronidazole on improving psoriasis skin inflammation in
our limited case study. Using microarray data, we showed
that recognition of the role of abnormal nickel concentration
could point the way to greater understanding of psoriasis
pathogenesis.
e:
saed.sayad@utoronto.caBiomarkers and psoriasis
Saed Sayad
University of Toronto, Canada