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Journal of Neurology and Neurorehabilitation Research | Volume 3
August 23-24, 2018 | Paris, France
Neurology and Neurological Disorders
18
th
International Conference on
Tau protein in the retina
Umur Kayabasi
1
and
John Rose Sr
2
1
Bahcesehir University, Turkey
2
John Rose Eye Center, United Kingdom
Background:
Recent research suggests that Tau is the culprit
lesion along with neuroinflammation in the etiology of
Alzheimer’ s Disease (AD). Retina is the extension of the
brain and is the most easily approachable part of the central
nervous system. Detection of the pathological protein
accumulations may be possible by using spectral domain
optical cohere scent tomography (SD-OCT) and fundus auto
fluorescein (FAF). There is evidence showing that retinal
plaques start accumulating even earlier than the ones in the
brain. Most recent Tau protein images in the brain consist
of normal or reverse C-shaped paired helical filaments.
Methods:
20 patients with PET proven AD were examined by
SD-OCT and FAF. Mean age was 72. Hypo or hyperfluorescent
retinal lesions were scanned by SD-OCT and C shaped
paired helical filaments were investigated in a masked
fashion. The researchers agreed on the shape of the
lesions. Both C-shaped (normal or reverse) filaments and
thinner fibrillary structures were taken into consideration.
Results:
In all the patients, paired helical filaments that exactly
corresponded with the histopathologic and cryo-EM images of
Tau (Figure 1) in terms of shape and dimension were detected
along with thin fibrils and lesions similar to amyloid beta. The
number of the retinal filaments and other abnormal proteins
was in concordance with the severity of the disease process.
The advanced retinal filaments had normal or reverse paired C
shapes (Figure2) andthinfibrilshadtheshapeofhistopathologic
images seen in early developmental stages of the disease.
Conclusions:
Retinal images of Tau were disclosed for the
first time in live AD patients. Retinal neuroimaging is a
trustable biomarker and tool for monitoring the disease.
e:
kayabasi@yahoo.com