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November 22-23, 2018 | Paris, France
Journal of Materials Science and Nanotechnology | Volume: 2
Materials Physics and Materials Science
International Conference on
Hyphenated Mass Spectrometric techniques for smart materials architecture: Theranostic applications
Hossam E M Sayour
Biomedical Chemistry Unit, Egypt
R
apid early detection is crucial for transboundary/
emerging/ zoonotic disease outbreak prevention. Several
international organizations such as WHO, OIE, FAO and EPA
called upon the development of rapid, sensitive, low cost,
and easy to use early diagnosis of pathogens as “rapid field
tests” or “point of care diagnostics”. Molecular recognition
plays an important role in biological systems and is observed
in between receptor-ligand, antigen-antibody, DNA-protein,
sugar-lectin, RNA-ribosome, substrate-enzyme, etc. (The
lock and the key theory, Pauling, 1940). My investigations
show that the characteristics of the functional biomimetic
system of “molecular architecture” for certain biological
organisms and systems should be designed by computational
approach. Molecular imprinted polymers (MIPs) have been
applied as artificial antibodies, catalysts, sensors, drug assay
tools, and affinity separations. Targets including epitopes
or haptens, which are the major antigenic determinants of
microorganisms like bacteria or viruses, lead to innovations
in disease theragnosis. MALDI-TOF MS bio typing was highly
successful in rapid identification of Brucella cultures through
dendrodrogram analysis, despite the high phenotypic and
genotypic similarity among members of the genus Brucella.
From the species perspective, B. suis and B. ovis were
more related to B. melitensis than to B. abortus, which
had a separate cluster. Strain-specific mass spectral peaks
were observed among almost all strains examined Tandem
mass spectrometric experiments reveal individual polymer
end groups; in contrast, the 1-D MS spectrum provides
insight about the sum of chain end substituents present in
the oligomer, which may also contain partial or complete
monomer unit(s). Additionally, MS can be employed to
analyze copolymer sequences and to differentiate polymer
architectures. Hyphenated mass spectrometric techniques
are machines driving these innovations to successful
marketable products based on patents. Computational
chemistry tools will aid this developmental approach
upon conformational decisions of diagnostic biomarkers/
biomimetic smart polymers.
e:
soomy111@yahoo.com