materials-physics-2018-posters-abstracts

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November 22-23, 2018 | Paris, France

Journal of Materials Science and Nanotechnology | Volume: 2

Materials Physics and Materials Science

International Conference on

High voltage nano-electrospray ionization Mass Spectrometry for aqueous solution

Md Matiur Rahman

Beijing Institute of Technology, China

ano electrospray (nESI) has widely been used in the

field of chemistry, biology, medicine, pharmaceutical

industry, clinical assessment and forensic science. nESI can

be done without corona discharge if the sample is prepared

in organic solvent. The corona discharge is typically observed

in negative ion mode at nESI emitter tip under high aqueous

solvent conditions, resulting in low ion intensity. The corona

discharge can be quenched using a 10 GΩ resistor between a

pulled glass capillary and high voltage power supply. In order

to elucidate the scenario of the adduct of Na

and enhanced

the signal intensity of peptides and proteins, a high-voltage

is applied to nanocapillary and compared with conventional

nESI in this study. Different proteins and peptides could

be selected and assessed using Bruker-HCT ion trap mass

spectrometer. The performance of high voltage-nESI could

be superior to low voltage or conventional nESI in terms of

ion intensity and the effect of Na

adduct for the analysis of

biomolecule in aqueous solution.