materials-physics-2018-posters-abstracts

Page 30

Notes:

allied

academies

November 22-23, 2018 | Paris, France

Journal of Materials Science and Nanotechnology | Volume: 2

Materials Physics and Materials Science

International Conference on

PTR-TOF-MS a new tool for volatilome investigation of autoimmune diseases

Julia Ricanyova

Breathe Research Institute, Austria

publication issued by the World Health Organization

(WHO) in 2006 pointed out that: autoimmune diseases are

multifactorial. Both intrinsic factors (e.g. genetics, hormones,

age) and environmental factors (e.g. infections, diet, drugs,

and environmental chemicals) may be responsible for them.

Bacterial, viral and yeast infections are associated with many

autoimmune diseases as well as chronic fatigue syndrome.

When considering these biological ranges of selected volatile

organic compounds (VOCs), personal factors such as race,

age, gender, weight, food consumption, medication, illicit

drugs, and even profession/class have to be taken into account

for autoimmune diseases. Advances in multiplexed assay

technology at the gene, protein, and cellular level have enabled

the identification of potential biomarkers by PTR-TOF-MS.

Analysis of VOCs or volatilome have been investigated from

human exhaled breath. New tool PTR-TOF-MS provide deep

insight into the status of various biochemical processes in the

human body. Selected VOCs have been considered as potential

biomarkers of immune-pathophysiological processes related to

autoimmune diseases. PTR-TOF-MS of breathe VOCs analysis is

noninvasive and fast biomonitoring with potential for the early

detection of autoimmune diseases like rheumatoid arthritis,

lupus and sjorgren´s syndrome. Typical scan andMID spectrums

for an on-line real-time breath sampling of selected protonated

ions related m/z were monitored. This poster gives an overview

of themajor VOCs measured in human exhaled breath, possible

biochemical pathways of breath VOCs generation, diagnostic

importance of their analysis, and analytical techniques used in

the breath test.

Speaker Biography

Julia Ricanyova has completed her PhD at the age of 27 years from Nicolaus Copernicus

University in Poland and P J Safarik University in Slovakia. She is the researcher of ChemMS

Labs, Swiss. She has just 8 publications that have been cited over 100 times, attendedmore

than 30 conferences, and her publication H-index is 5.