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Allied J Med Res 2017
Volume 1 Issue 2
Herbal Medicine 2017
September 01-02, 2017 London, UK
3
rd
International Conference and Expo on
Herbal & Alternative Medicine
Page 62
Novel antioxidant potential of commonly used
plants of Unani system of medicine
Sharmila Chattopadhyay and Mehar D Kalim
CSIR-Indian Institute of Chemical Biology, India
R
eactive oxygen species (ROS) mediated oxidative
stress, which is involved in several pathological
diseases, such as cancer, atherosclerosis, diabetes,
inflammation, and aging considered as serious concern
globally. Natural antioxidants are playing a leading role
to control these devastating conditions. Exogenous
dietary antioxidants, called nutraceuticals, are capable
of scavenging ROS and have shown potential promise
in preventing certain disease conditions. Present
investigation has been designed to explore the antioxidant
potential of five plants routinely used in the Unani system
of medicine. For that, several plants were screened
for ROS scavenging activity, and five plants showed
better results were selected for further evaluation. 50%
aqueous-methanol extracts were prepared from these five
Unani plants, viz.
Cleome icosandra, Rosa damascena,
Cyperus scariosus, Gardenia gummifera, and Holarrhena
antidysenterica
and their
in vitro
scavenging of DPPH,
ABTS+, and capacity to prevent oxidative DNA damage
were determined. Cytotoxic activity was also determined
against the U937 cell line and showed no toxicity. The
total phenolic, flavonoid and ascorbic acid contents of
the extracts were in the ranges 62.89±0.43 - 166.13±0.56
mg gallic acid equivalent (GAE)/g extract, 38.89±0.52 -
172.23±0.08 mg quercetin equivalent (QEE)/g extract and
0.14±0.09 - 0.98±0.21 mg AA/g extract. In conclusion,
these routinely used Unani plants, viz.
C. icosandra, R.
damascena and C. scariosus
, reported to have significant
activity against several human ailments, could be
exploited as potential sources of natural antioxidants as
well as towards the development of dietary antioxidants
or nutraceuticals.
sharmila@iicb.res.inAllied J Med Res 2017