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Allied J Med Res 2017
Volume 1 Issue 2 Herbal Medicine 2017
September 01-02, 2017 London, UK
3rd International Conference and Expo on
Herbal & Alternative Medicine
Page 55
Andrographis paniculata for symptomatic
relief of respiratory tract infections (RTIs) in
adults and children: a systematic review
Martin Logue
University of Southampton, UK
Background: Antimicrobial resistance is a major threat to
global healthcare systems. Safe and effective alternatives
to current antimicrobials are required. Andrographis
paniculata (A. paniculata) is used in Western, Chinese and
Ayurvedic herbal traditions for the treatment of respiratory
conditions including cough, cold, sinusitis and influenza.
This systematic review aimed to evaluate the clinical
effectiveness and safety of A. Paniculata for symptoms
of acute RTIs.
Methods: English and Chinese databases were searched
from their inceptions to March 2016 for randomized
controlled trials (RCTs) evaluating oral A. paniculata.
Primary outcomes were improvement in RTI symptoms
and adverse reactions. Random effects model was used
to pool the mean differences and risk ratio with 95% CI
reported. Methodological quality was evaluated using
the Cochrane risk of bias; two reviewers independently
screened eligibility and extracted data.
Results: Thirty-three RCTs (7175 patients) were included.
Interventions included A. paniculata as a monotherapy
and as an herbal formulation. Most trials evaluated A.
paniculata provided commercially but seldom reported
GMP details. There was a statistically significant effect in
favor of A. paniculata versus placebo (n=445, SMD: -0.69,
95% CI [-1.26, -0.12] for overall symptom; n=596, SMD:
-0.39, 95% CI [-0.67, -0.10] for cough; and n=314, SMD:
-1.13, 95% CI [-1.37, -0.89] for sore throat). Favorable
effects were shown when A. paniculata was compared to
standard care, and other herbal interventions. No major
AEs were reported. The methodological quality of included
trials was limited.
Conclusion: A. paniculata appears beneficial and safe for
relieving RTI symptoms and shortening time to symptom
resolution. Due to limited study quality and heterogeneity,
the evidence reviewed is inconclusive. Well-designed trials
evaluating the effectiveness and safety of A. paniculata
are warranted.
Allied J Med Res 2017