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Allied J Med Res 2017
Volume 1 Issue 2
Herbal Medicine 2017
September 01-02, 2017 London, UK
3
rd
International Conference and Expo on
Herbal & Alternative Medicine
Page 54
Protective effect of the standardized extract
of Holmskioldia sanguinea on tumor bearing
mice
Mahesh Pal, Tripti Mishra, Ch V Rao and D K Upreti
CSIR - National Botanical Research Institute, India
C
ancer has been considered to be very dreadful
disease.
Holmskioldia sanguinea
is a large climbing
shrub found in the Himalayas at an altitude of 5,000 ft and
preliminary investigation showed the excellent yield of
andrographolide and subjected for the anticancer activity.
Protective effect of
Holmskioldia sanguinea
leaf ethanolic
extract has been investigated against Ehrlich ascites
carcinoma (EAC) and Daltons ascites lymphoma (DAL) in
Swiss albino mice and to evaluate the possible mechanism
of action. The enzymatic antioxidant status was studied
on tumor bearing mice, which shows the potential of the
compound to possess significant free radical scavenging
property and revealed significant tumor regression and
prolonged survival time. The isolated bioactive molecule
andrographolide from
Holmskioldia sanguinea
yields
(2.5%) in subject to HPTLC/HPLC analysis. The cellular
defense system constituting the superoxide dismutase
catalysis was enhanced whereby the lipid peroxidation
content was restricted to a larger extent. The
Holmskioldia
sanguinea
is a new source of andrographolide and
demonstrated the potency in treatment of cancer.
drmpal.nbri@rediffmail.comAllied J Med Res 2017