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allied
academies
J u n e 2 8 - 2 9 , 2 0 1 8 | A m s t e r d a m , N e t h e r l a n d s
Joint Event on
OBESITY AND WEIGHT MANAGEMENT
VACCINES AND IMMUNOLOGY
&
International Conference on
International Conference on
Asian Journal of Biomedical and Pharmaceutical Sciences
|
Volume 8
ISSN:
2249-622X
ADIPOKINES MAY MEDIATE THE
RELATIONSHIP BETWEEN RESTING
METABOLIC RATES AND BONE
MINERAL DENSITIES IN OBESE
WOMEN
Khadijeh Mirzaei, Moradi S, Abdurahman AA
and
Keshavarz SA
Tehran University of Medical Sciences, Iran
Introduction:
The researchers sought to test the possible link between resting
metabolic rate and bonemineral density through four adipokines. Participants
with lower resting metabolic rate (RMR) per kilogram demonstrated higher
total bone mineral density (BMD), total T-score, and total Z-score. Omentin-1
had a mediatory effect on the relationship between RMR/kg of body weight
and bone parameters. The previous results of studies regarding the links
between obesity and bone health are controversial. For this reason, the
researchers sought to test the possible link between RMR and BMD through
the following four adipokines: vaspin, retinol binding protein 4, angiopoietin-
like 6 (ANGPL6), and omentin-1.
Methods:
We enrolled 312 obese Iranian women (30 ≤ body mass index <40)
in this cross-sectional study. In order to examine the association of serum
adipokine levels with RMR and BMD, the participants were grouped based on
RMR per body weight. Body composition, dietary intake, bone mineral density,
and resting metabolic rate were assessed in all participants. Serum adipokine
levels were quantified by the enzyme-linked immunosorbent assay (ELISA)
method.
Results:
Low levels of RMR/kg were strongly associated with higher weight,
body mass index, fat mass, and visceral fat levels. In fact, participants with an
RMR/kg of body weight <20 kcal/24 h/kg were more obese (p<0.05). Another
noteworthy finding was that participants with lower RMR/kg demonstrated
higher total BMD, total T-score, and total Z-score. Our results showed that
omentin-1 had a mediatory effect on the relationship between RMR per
kilogram of body weight and bone parameters (p<0.05). Nevertheless, other
adipokines such as vaspin, retinol-binding protein 4 (RBP4), and ANGPL6 did
not affect the relationship between RMR and BMD (p>0.05).
Conclusions:
The inhibitory effect of omentin-1 on TNF-alpha seems to be
able to reduce the amount of circulating leptin as adipokine, affecting energy
expenditure and improving bone loss induced by estrogen deficiency and
controlled effect of RMR on BMD.
Khadijeh Mirzaei is working as a Professor in
Department of Community Nutrition at Tehran
University of Medical Sciences, Iran.
mirzaei_kh@tums.ac.irBIOGRAPHY
Khadijeh Mirzaei et al., Asian J Biomed Pharmaceut Sci 2018, Volume 8 | DOI: 10.4066/2249-622X-C1-002