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Journal of Clinical and Experimental Toxicology | Volume: 3
February 21-22, 2019 | Paris, France
International Conference on
Environmental Toxicology and Pharmacology
Evaluation of analgesic and anti-inflammatory potential of SPBV-02 in rodents
Saraswati Patel
Banasthali Vidyapith, India
The aim of the present study was to evaluate anti-
inflammatory and analgesic potential of SPBV-02 (In-silico
derived) using robust rodent models. The anti-inflammatory
activity of SPBV-02 was investigated using carrageenan-
induced paw edema and acetic acid induced vascular
permeability in rats. Further, analgesic potential of SPBV-02
was screened using acetic acid induced writhing, eddy’s hot
plate induced algesia, tail immersion induced algesia and
formalin test in rats. The results of present investigation
revealed that oral administration of SPBV-02 (0.1mg/kg and
0.2mg/kg, orally) in carrageenan induced paw edema and
acetic acid induced vascular permeability in rats produced
a significant reduction in paw edema and dye extravasation
in peritoneal fluid respectively in a dose dependent manner.
Similarly, a prominent reduction in number of writhing
and paw licking was also observed in acetic acid induced
writhing and formalin test in rats. Moreover, SPBV-02 also
exhibited a marked reduction in paw withdrawal latency in
eddy’s hot plate induced algesia and tail withdrawal latency
in tail immersion induced algesia in rats in a dose dependent
manner. In acetic acid induced pleurisy model, antioxidant
studies revealed reduction in concentration of proteins and
nitric oxide with marked elevation of superoxide dismutase
and reduced glutathione enzymes in lung. Histopathology
study of lung clearly indicated protective roles of SPBV-02 in
acetic acid induced pleurisy model.
The results concluded that SPBV-02 has remarkable anti-
inflammatory and analgesic potential. Yet advanced studies
are needed to elucidate the possible mechanism of action of
test compounds.
Speaker Biography
Saraswati Patel is currently working as a Ph.D scholar in Banasthali Vidyapith, India. Her
area of interest are Metabolic diseases and their management and Molecular genetics.
She has attended Fifteen days training programme on animal handling, models of
pharmacological screening and instrumentation from Pinnacle Biomedical Research
Institute (PBRI), Bhopal, India during 26th Dec, 2014 to and 7th Jan, 2015.
e:
Saraswati Patel, J Clin Exp Tox, Volume 3
DOI: 10.4066/2630-4570-C1-006