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Journal of Clinical and Experimental Toxicology | Volume: 3
February 21-22, 2019 | Paris, France
International Conference on
Environmental Toxicology and Pharmacology
Metabolomics: A novel tool of Precision Medicine
Dimitris Tsoukalas
President of the European Institute of Nutritional Medicine, Greece
D
ramatic changes of the environment in the last decades have
resulted in nutrient poor food and excessive intake of heavy
metals and toxins through air, drinking water and dietary habits.
Non-communicable diseases (NCD) which are responsible for
almost 70%of global deaths aremainly caused bymodifiable risk
factors. These include behavioral and metabolic risk factors such
as unhealthy diet, tobacco smoke and alcohol. Epigenetic factors
havehighattributablerisksof80%formostNCD.Precisionmedicine
integrates the individual variability in genes, environment, and
lifestyle of each person for the prevention and treatment of
disease. Metabolomics, the quantitative and comprehensive
evaluation of metabolites, has emerged as a novel and powerful
tool in precision medicine. As one of the “omics” technologies,
metabolomics has attracted increasing attention for its potency
in identifying unique biomarkers. Metabolites provide a detailed
overview of cellular function. Analysis of metabolites gives a
precise data of nutritional deficiencies, metabolic imbalances,
environmental toxins, microbiome condition, and uncovers
underlying genetic predispositions that can be modified through
diet, lifestyle, supplements ormedications. Gas chromatography/
Mass spectrometry methodology has allowed the detection of
low quantity molecules in minimum amount of biofluid samples.
Critical signs of systemic dysfunction at the molecular level are
revealed years before clinical symptoms appear. Thus, through
the assessment of the overall health status, early detection of a
disease and intervention to restore these deficiencies is feasible.
e:
dr.tsoukalas@gmail.comJ Clin Exp Tox, Volume 3
DOI: 10.4066/2630-4570-C1-006