6 / 22
Page 30
Notes:
allied
academies
Journal of Clinical and Experimental Toxicology | Volume: 3
February 21-22, 2019 | Paris, France
International Conference on
Environmental Toxicology and Pharmacology
Neuroprotective effects of BVSJ-05/06 compounds on Scopolamine Induced Amnesia in
experimental rodents
Smita Jain
Banasthali Vidyapith, India
A
lzheimer’s disease (AD) is a chronic neurodegenerative
disorder that leads to disturbances of cognitive functions.
Present study was designed to evaluate the neuroprotective
effect of (In-silico derived) BVSJ-05/06 compounds in
scopolamine-induced alzheimer albino rats. BVSJ -05 (2.5mg/
Kg and 5mg/Kg), BVSJ-06 (5mg/Kg and 10mg/Kg) was orally
administered for 7 successive days. Alzheimer was induced
at the end of the treatment period by a single injection of
scopolamine (0.3 mg/kg; i.p.). Anti-Alzheimer activity was
evaluated in radial arm maze assay, water morris maze assay,
cross gap assay and olfactory recognition assay in albino rats.
In addition, certain inflammatory and oxidative stress markers
as well as histopathologic studies were performed. Pre-
treatment of with BVSJ-05/06 showed a significant reduction
in reference and working memory, transfer latency with
elevation in recognition frequency in respective cognition
model radial arm maze assay, water morris maze assay,
cross gap assay and olfactory recognition assay. Biochemical
markers such as elevation of superoxide dismutase, reduced
glutathione and catalase with reduction of AchE level were
observed and histopathological study of hippocampus region
in rat brain revealed the reversal of neuronal damage in the
treatment group (P < 0.05) when compared to scopolamine-
treated control group. In conclusion, BVSJ-05/06 has
demonstrated promising anti-alzheimer like effects and
requires in-depth screening to ascertain exact mode of action.
Speaker Biography
Smita Jain has completed Diploma in MEDICAL IMAGE PROCESSING from Banasthali
Vidyapith University. She did Advance Diploma in MEDICAL IMAGE PROCESSING from
Banasthali Vidyapith University. She got a Certificate in STASTICAL SOFTWARE from
Banasthali Vidyapith. She has received gold medal in her master’s research project by
Vice Chancellor of Oxford University.
e:
smitajain1994@gmail.comSmita Jain, J Clin Exp Tox, Volume 3
DOI: 10.4066/2630-4570-C1-006