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Journal of Clinical and Experimental Toxicology | Volume: 3
February 21-22, 2019 | Paris, France
International Conference on
Environmental Toxicology and Pharmacology
Studies on Anti-Depressant activity of
Spathodea campanulata
in rodents
Ritika Gururani
Banasthali Vidyapith, India
Background and Aim:
Spathodea campanulata
(S. campanulata)
(family: Bignoniaceae) is a flowering tree and is native to Africa
and Southern Asia. Traditionally,
S. campanulata
is useful
in treatment of fever, malaria, diabetes, skin disease, filaria,
gonorrhea, epilepsy and mental disorders.
Experimental Procedure:
The current study investigated
antidepressant activity of ethyl acetate and methanol
extracts of
S. campanulata
flowers using two models viz.
forced swim test and tail suspension test. Methanol extract
of
S. campanulata
exhibited impressive antidepressant
activity in both the models and was further evaluated in
lithium induced head twitches and open field test models.
Further, a flavonoid was isolated from the methanol extract
by column chromatography and characterized by different
spectroscopic techniques. Depression is primarily associated
with deficiency of monoamines in different regions of brain,
therefore an attempt was also made to examine possible
mode of antidepressant action of isolated flavonoid by
determination of monoamines and their metabolites levels
in the different regions of mice brain.
Speaker Biography
Ritika Gururani has completed M.Pharm with thesis titled: “Assessment of anti-
diabetic and hypolipidemic activity of selected compounds in albino rats” from
Banasthali University, Rajasthan, India with 74% marks and stood second in order of
merit in the year of 2017. Her area of interest is Research and Development in the
field of pre-clinical pharmacology and molecular biology. She has published a research
paper “Discovery of Novel Soluble Epoxide Hydrolase Inhibitors as Potent Vasodilators”
in scientific reports.
e:
gururaniritika@gmail.comRitika Gururani, J Clin Exp Tox, Volume 3
DOI: 10.4066/2630-4570-C1-006