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Journal of Clinical and Experimental Toxicology | Volume: 3
February 21-22, 2019 | Paris, France
International Conference on
Environmental Toxicology and Pharmacology
Can we tame Glucocorticoids? Blood tyrosine as a new laboratory test
Irma Th Rass
Academy of Sciences, Russia
G
lucocorticoid (GC) preparations are used in medicine for
about 70 years as the most powerful anti-inflammatory
drugs also possessing immunosuppressive, anti-allergic
and antitoxic properties. However, application of these
unique preparations is associated with nearly inevitable
serious adverse effects and a difficulty of their withdrawal.
It is very important that the adverse effects are caused not
by toxic action of GC preparations but by their hormonal
nature. Glucocorticoid hormones directly or indirectly
control virtually all metabolic and physiological processes
in the body. However, for these virtually omnipresent and
vitally important hormones there is no representative
specific index of action similar to blood content of glucose
for insulin. The present paper considers specific features of
tyrosine metabolism that allows us to consider changes in
blood tyrosine content as manifestation of regulatory action
of GCs. Changes in blood tyrosine content were compared
with using GC preparations in two typical cases: in systemic
lupus erythematosus and in congenital adrenal virilizing
dysfunction in children. Blood tyrosine behaviour was also
considered in rats after adrenalectomy and on injecting
them with hydrocortisone. Based on these observations, it is
proposed to use blood content of tyrosine as a laboratory test
for reasonable prescribing GC preparations and monitoring
their dose. Blood tyrosine behavior in comparison with
adrenocortical response is also considered in influenza.
e:
irma2@kmail.ruJ Clin Exp Tox, Volume 3
DOI: 10.4066/2630-4570-C1-006