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allied
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Journal of Biotechnology and Phytochemistry
Volume 1 Issue 3
Chemistry World 2017
Notes:
Page 47
November 13-15, 2017 Athens, Greece
7
th
World Congress on
Chemistry
Application of the ALA-SCAN method in drug
discovery and pharmacodynamics
Cenk A Andac
Istinye University-Istanbul, Turkey
I
n drug discovery and pharmacodynamics, alanine
scanning (ALA-SCAN) is a method used to determine the
contribution of an aminoacid residue (other than alanine
or glycine) to the stability or function of a given protein or
peptide. In addition, point-mutations to alanine (or glycine)
allows researches to determine essential/non-essential
interactions between the peptide/non-peptide ligands and
their receptors, which provide crucial information in drug
discovery. In vivo applications of the ALA-SCAN technique
involves site-directed mutagenesis or random mutations
constituted by PCR library, which may be costly. On the
other hand, a more cost-effective method of ALA-SCAN has
been computationally utilized in theoretical chemistry. Here,
specific examples for the in-silico version of the ALA-SCAN
technique applied in our computer-assisted drug development
laboratory will be given.
Biography
Cenk A Andac works as an Assistant Professor in the School of Pharmacy at
Istinye University-Istanbul,Turkey. He has completed his Master’s degree and
PhD work as the Faculty of Pharmacy at the University of Wisconsin-Madison,
WI, USA (UW-Pharmacy, USA). He had been involved in teaching Drug
Actions & Delivery, and Pharmaceutical Biochemistry & Biotechnology courses
at UW-Pharmacy, USA for four and half years. He has also taught Medical
Pharmacology courses as an assistant professor for three years in Medical
school in Turkey. His current researches are development of novel anticancer
agents inhibiting G-coupled receptors in cancer stem cells; development of novel
aminoglycoside antibiotics; determination of 3D structures of biological and
synthetic compounds by NMR techniques; computer-assisted drug development
by AMBER, CHARMM and Quantum mechanics; Pharmacokinetics and
Pharmacodynamics properties of drug-receptor interactions. He currently holds
a patent for a potentially active anti-cancer agent against breast cancer.
cenk_andac@yahoo.comCenk A Andac, J Biotech and Phyto 2017