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allied
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Journal of Biotechnology and Phytochemistry
Volume 1 Issue 3
Chemistry World 2017
Notes:
Page 39
November 13-15, 2017 Athens, Greece
7
th
World Congress on
Chemistry
Lanthanide complexes – synthesis, characterization
and biological evaluation
Irena Kostova
Medical University - Sofia, Bulgaria
T
here is an increasing requirement for the discovery of
new metal-based compounds having better activities
than their precursors. Recently a number of lanthanide(III)
complexes were reported. These studies highlighted the
potential of developing novel lanthanide complexes with
improved biological potency. As a part of our continuing
work on the synthesis, characterization and applications
of lanthanide(III) complexes, it was observed that changes
in ligands and reaction conditions had profound effects on
selectivity and activity of the products obtained. The present
work deals with the synthesis, theoretical, analytical, NMR,
FT-IR and FT-Raman spectral investigations, supported by
DFT calculations, to understand the structural and bonding
features, the intramolecular interactions of biologically
active ligands and their lanthanide(III) complexes. Detailed
spectral analysis based on both calculated and experimental
data confirmed the suggested metal–ligand binding mode.
The recorded spectra and the marker bands of characteristic
functional groups were identified, in order to use them as
data bank for further application in trace analysis of rare-
earth complexes. The overall results confirmed that the
DFT approximation is a reliable method for calculations of
geometries and vibrational frequencies of the tested ligands
and their lanthanide(III) complexes. The cytotoxic effects on
different tumor cells and antioxidant activity of the complexes
were studied in order to set up a sequence of experimental
assays
in vitro
which allow predicting their activity
in vivo
.
Our investigations have shown that the complexes reveal
promising pharmacological properties more pronounced
than for the respective ligands and should be subset to further
detailed pharmacological and toxicological evaluation.
Biography
Irena Kostova has graduated from Mendeleev University - Moscow with the
highest grade. She has been appointed as a Research Scientist at Ministry of
Environmental. Her PhD and DSc thesis has been awarded by MU-Sofia which
is established and maintains relationships with many European Universities.
She has published hundreds of publications with more than 3300 citations
(IF>150; h-index: 27), scientific book chapters and books for students. Her
research interests include the developmental work of coordination chemistry,
vibrational spectroscopy, pharmacological investigations etc.
irenakostova@yahoo.comIrena Kostova, J Biotech and Phyto 2017