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Asian Journal of Biomedical and Pharmaceutical Sciences | ISSN: 2249-622X | Volume 8
&
Joint Event
Chemistry and Organic Chemistry
Biomedicine & Pharmacotherapy
International Conference on
8th World Congress on
October 22-23, 2018 | Frankfurt, Germany
Synthesis and investigationof chemical structureof N-methyl N-benzyl chitosanby the co-alkylationmethod
Shamo Z Tapdiqov
Azerbaijan National Academy of Sciences, Azerbaijan
Chitosanisalinearcationitetypenaturalpolyaminosaccharide
produced by N-deacetylation of chitin. Chitosan consists of
β-(1,4)-2-amino-2-deoxy-D-glucosamine and β-(1,4)-N-acetyl
D-glucosamineunits.Thenon-toxicity,biocompatibilityandbone
adhesion of chitosan confirm its perfect properties in delivery
of genes and drugs in medicine and biotechnology. Solubility
of chitosan only in acidic environment limits its use as a carrier
in controlled release of some drugs. Chitosan derivatives with
new properties were synthesized by graft copolymerization,
acylation, carboxymethylation, and alkylation reactions of
chitosan macromolecule. Such derivatives have new properties
and can be managed from a molecular structural and can easily
enter into electrostatic or hydrogen bond with low molecular
drug preparations.
In this research synthesis of Schiff derivatitive of chitosan with
methyl and benzyl aldehyde at the co-alkylation reaction. The
synthesis of N-methyl, N-benzaldehyde chitosanwas conducted
in two stages - initially by aryl-co-alkylation and then by the
reduction process.
The exchange of hydrogen atoms from 85-90% free –NH2
groups on the content of chitosan is commonly found to be
substituted by various alkyl and aromatic radicals based on
the Schiff reaction. In most cases included of alkyl or aryl
group into chitosan macromolecule with the addition of the
same radicals. Also, the degree of alkylation or arylation of
the amine groups ultimately affect the product’s solubility
and biological properties. The reaction mechanism and
molecular structure of product was studied by the UV-Vis
electron spectra was performed. It was determined besides
the chitosan, and the reduced chitosan derivatives were very
poorly soluble in water. High sensitive method has been used
in the discovery of the molecular structure of these polymer
modifications. The analysis of samples has been studied in
the ultraviolet region due to slight solubility.
Speaker Biography
Shamo Z Tapdiqov in 2011 obtained his Ph.D. degree from the Faculty of Macromolecular
Chemistry at the Institute Catalysis and Inorganic Chemistry Azerbaijan National
Academy of Sciences in Baku (Azerbaijan) and in 2016 he became the Assoc. Prof. in
the same field.
e:
Shamo Z Tapdiqov, Chemistry and Biomedicine 2018, Volume 8
DOI: 10.4066/2249-622X-C4-012