5 / 28
Page 47
Notes:
allied
academies
Cell Science, Stem Cell Research &
Pharmacological Regenerative Medicine
November 29-30, 2017 | Atlanta, USA
Annual Congress on
Adv cel sci tissue cul 2017 | Volume 1 Issue 2
Human c-Cbl and Cbl-b proteins are more highly expressed in the thymus compared to the testis
Mazo Kone
1, 2
, Rachida Salah
1
and
Harir Noria
1
1
Djillali Liabbes University, Algeria
2
University of Ibadan, Nigeria
Background & Objectives:
c-Cbl and Cbl-b are two
members of the Cbl family proteins, with a crucial role of
downregulation of tyrosine kinase receptors. They act as
E3 ubiquitin ligases and are multivalent adaptor proteins,
making them important in maintaining homeostasis in the
body. This study investigated the expression level in thymus
and testis in normal conditions.
Methods:
The expression level was assessed by immunochemistry
of tissuemicroarrays of normal thymus and testis biopsies.
Results:
Cbl-b and c-Cbl proteins were found to be
highly expressed in normal testis and thymus, indicated
as yellowish-brown granules in the cytomembrane and
cytoplasm compared to controls. The c-Cbl appears to be
more highly expressed than the Cbl-b in the thymus, while
c-Cbl appears slightly stronger than Cbl-b in the testis. The
thymus was found with a higher grade compared to testis.
Conclusion: In this work, we concluded that in normal
condition, thymus tissue expresses more Cbl family proteins
(c-Cbl and Cbl-b) than the testis tissue in humans.
Speaker Biography
Mazo Kone received basic training in biology of cancer, physiopathology of metabolic
diseases, infectious diseases and many more. However, he quickly developed an
interest for the molecular biology of cancer, physiology of the cell and infectious
diseases. He worked on the oncogenic properties of Human c-Cbl and Cbl-B as Master’s
project work. Currently, he is doing a Ph.D in Cell Biology and Genetics at the University
of Ibadan in Nigeria. His research is on congenital infections in pregnancy both in Mali
and Nigeria. In general, his research works are focused on molecular biology of cancer
and infectious diseases. He is the Leader of Rachetes Algeria since 2012, the promoter
and the manager of The Biomedical researcher project. He is a Lecturer in Mali
(Universite Scientique Libre de Bamako). He is also a writer and an author in personal
development. He likes research, teaching, reading and communication.
e:
mzoalger@yahoo.fr