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academies
Cell Science, Stem Cell Research &
Pharmacological Regenerative Medicine
November 29-30, 2017 | Atlanta, USA
Annual Congress on
Adv cel sci tissue cul 2017 | Volume 1 Issue 2
T
he growth of cancers depends on the formation of blood
vessels that provide the supply of nutrients and oxygen
and the nervous system acts as a crucial part of cancer
microenvironment. The angiogenesis and vasculogenesis are
essential during cancer progression. Recently, several studies
have reported that glioblastoma stem cells are able to give
rise to tumor vascular endothelial cells (ECs) and vascular
pericytes for tumor vascularization. However, there is no
evidence to show that the tumor stem cells from other kinds
of tumors including carcinoma produce endothelial cells to
constitute the functional blood vessels in cancer. In addition,
recent evidences have demonstrated that the stimulation of
both cancer growth and metastasis by members of nervous
system such as neurons. How the nervous system built in
cancer tissues is unknown. We transplanted the cancer
stem cells that were isolated from the patients with gastric
and colorectal carcinoma into nude mice via subcutaneous
and intraperitoneal injections to produce human cancer
xenografts. Then the innervations, angiogenesis were
examined and the origins of the neural cells and endothelial
cells were determined in cancer tissues. A single cancer stem
cell from the cancer tissues of human patients could generate
neurons including sympathetic and parasympathetic cells to
take part in the nervous system in cancer tissues. Knocking
down the neural generating capabilities of the human cancer
stem cell inhibited the growth of tumors. Next, we show
that cancer stem cells of the human colorectal carcinoma
(CoCSCs) give rise to vascular endothelial cells and compose
the vasculatures in cancer tissues. NuMA+ EC incorporated
blood vessels were functional. Our data demonstrate that
neural cells and endothelial cells originated from human
cancer stem cells constitute blood vessels and nerve system
for the cancer progression in the cancer tissues.
e:
xmingmo@scu.edu.cnThe constitution of the cancer tissues
Xianming Mo
Sichuan University, China