cell-science-pharmacology-2017-posters-abstracts

Page 67

allied

academies

Cell Science, Stem Cell Research &

Pharmacological Regenerative Medicine

November 29-30, 2017 | Atlanta, USA

Annual Congress on

Adv cel sci tissue cul 2017 | Volume 1 Issue 2

his Commentary examines an important clinical observation

that right-sided colorectal cancers appear less treatable

than the left-sided cancers. The concepts of the initiation/

promotion/progression /process, the stem cell hypothesis, the

role gap junctional intercellular communication, cancer cells

lacking GJIC either because of the non-expression of connexin

genes or of non-functional gap junction proteins and the role

of the microbiome in promoting initiated colon stem cells to

divide symmetrically or asymmetrically are examined to find an

explanation. It has been speculated that embryonic-like lesions

in the ascending colon are initiated stem cells, promoted via

symmetrical cell division, while the polyp-type lesions in the

descending colon are initiated stem cells stimulated to divide

asymmetrically. To test this hypothesis, experiments could

be designed to examine if right-sided lesions might express

Oct4A

and

ABCG2

genes but not any connexin genes, whereas

the left-sided lesions might express a connexin gene, but not

Oct4A

or the

ABCG2

genes. Treatment of the right sided lesions

might include transcriptional regulators, whereas the left-sided

lesions would need to restore the posttranslational status of the

connexin proteins.

What roles do colon stem cells and gap junctions play in the left and right location of origin of colorectal

cancers?

James E Trosko

and

Heinz-Josef Lenz

Michigan State University, USA

USC Norris Comprehensive Cancer Center, USA