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Page 44
allied
academies
Journal of Nutrition and Human Health | Volume 2
&
October 29-30, 2018 | London, UK
Joint Event
Nutrition and Fitness
16
th
International Conference on
3
rd
World Congress on
Card i o l ogy
Notes:
Physical activity protects the vascular dysfunction in obesity
Yoonjung Park
University of Houston, USA
O
besity is associated with various cardiovascular disease
and physical inactivity is one of the major causes of this
pathology. We investigated the protective effect of physical
activity on the coronary vascular dysfunction in obesity and
its potential underlying mechanisms. Four groups of mice,
1] Control low-fat diet (LF-SED), 2] LF diet with free access
to a voluntary running wheel (LF-RUN), 3] High-fat diet (HF-
SED; 45% of calories from fat), and 4] HF-RUN, were utilized
for the study. The endothelium-dependent vasodilatory
function of isolated coronary arterioles and contributing
factors to this vascular dysfunction were measured. We
found that, despite high-fat diet, voluntary running (HF-RUN)
improved acetylcholine (ACh)-induced and flow-induced
vasodilatory function, endothelial nitric oxide synthase
(eNOS) expression, leptin signals, and antioxidant enzymes
expression, but decreased inflammation and oxidative
stress in coronary arterioles compared to obesity mice (HF-
SED). These findings suggest that physical activity protects
the coronary vascular dysfunction in high-fat diet-induced
obesity via multiple mechanisms including endothelial
nitric oxide synthase (eNOS), leptin and redox balance.
e:
ypark10@uh.edu