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Asian Journal of Biomedical and Pharmaceutical Sciences | Volume 8
May 14-15, 2018 | Montreal, Canada
Global Summit on
Biopharma & Biotherapeutics
T
ransdermal drug delivery including topical application is
regarded as a potential route of delivering therapeutics
that is capable of overcoming limitations of oral delivery and
hypodermic injections. Among transdermal drug delivery
systems,microneedles have gainedahigh interest due to their
ability in delivering drugs with a high efficacy compared with
topical application. Microneedles are referred to microscopic
needles that are capable of delivering therapeutics into the
skin in a minimally invasive manner. There are three main
categories of microneedles; hollow type, solid type and
dissolving type. Dissolving microneedles are polymeric
structures fabricated over a patch that encapsulate drug and
deliver it into skin upon application. However, due to stiffness
of skin, only small portion of therapeutics are delivered into
the skin. Therefore, we developed a patch-less dissolving
microneedle delivery system which delivers microneedles
into skin through micro-pillar structures without causing
pain in less than a second. We have also developed novel
microneedle fabrication techniques by which activity of
encapsulated biotherapeutics can be maintained at high
activity levels during the fabrication process.
e:
hijung@yonsei.ac.krMicro needles: A novel and minimally-invasive drug delivery approach to overcome limitations of
hypodermic needles for bio pharmaceutics
Hyungil Jung
Yonsei University, South Korea