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allied
academies
Asian Journal of Biomedical and Pharmaceutical Sciences | Volume 8
May 14-15, 2018 | Montreal, Canada
Global Summit on
Biopharma & Biotherapeutics
F
ast-dissolving
formulations
represent
excellent
opportunities for life cycle management to the
pharmaceutical companies. Fast dissolving technologies have
many advantages like ease of swallowing, administration
without water, quick onset of action for improving both
patient convenience and compliance as benefits for the
patient; extended life cycle, product differentiation, patent
protection as benefits for pharmaceutical companies. But,
there are some challenges for formulation development
studies like taste-masking, disintegration time, moisture
sensitivity, friability, packaging and intellectual property
issues, especially for the generic companies. The technologies
are under patent protection like Zydis®, Flashtab®, OraSolv®
and DuraSolv™, WOWTAB®. One of the major issues is
a taste-masking problem may be overcome with using
cyclodextrins, polymer coating, flavoring and sweetening
agent, microencapsulation techniques. There are some
modified excipients for providing both taste-masking and
productability properties in the formulation like Ludiflash®,
Pharmaburst® etc. From the analytical development point
of view, there are a number of different methods from
conventional dosage forms which are determined in the
Pharmacopoeias. And for comparison and assessment of
taste masking, electronic tongue may be a good opportunity
which was developed by Alpha MOS. In the sense of generic
companies, developing a fast dissolving tablets version
of an existing immediate-release product means that the
two formulations must be bioequivalent, and this can be
challenging for
in vivo
studies especially if themethod of taste
masking retards the dissolution rate of the active ingredient
after disintegration. What about the future of fast dissolving
technologies? Orally disintegrating extended release (ODT-
ER) dosage forms are providing all of the benefits of these
two drug delivery technologies in a single pharmaceutical
product. And oral rapid films also may be a good alternative,
especially for the OTC market.
e:
gulayelken@gmail.comFast dissolving drug delivery systems
Gülay Yelken Demire
Sanovel Pharmaceuticals, Turkey