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Asian Journal of Biomedical and Pharmaceutical Sciences | Volume 8
May 14-15, 2018 | Montreal, Canada
Global Summit on
Biopharma & Biotherapeutics
Objective:
The 18F-labeled Deoxy-D-Glucose exhibits high
affinitytocancertissueasaPET(PositronEmitionTomography)
imaging agent for metastatic cancers. Complexation of 10B to
18F-DG complex may create a useful BNCT (Boron Neutron
Capture Therapy) agent for cancer therapy. In previous
studies, complexation and characterization of 10B with DG
was evaluated and bio distribution analysis was completed
successfully. Radio labelled 10B-DG will be useful approach
for uses for BNCT applications.
Methods:
The 18F-DG synthesized by ion exchange and
complexed with 10B(OH)3 via pH reactions. 18F-DG-10B
complexation was assayed with Agilent 1260 Infinity HPLC-
DAD and Agilent 6420 Triple Quad LC/MS. Complexed
molecule defragmented and fragmentation products assayed
with Agilent 6420 Triple Quad LC/MS for confirmation.
Results:
10B-18F-DG complex was obtained with ion-
exchange pH reaction successfully. Complexation of two
10B(OH)3 to 18F-DG was determined with Triple Quad LC/
MS. Purification of 10B-18F-DG is currently in progress.
Conclusions:
Radio-labelled 10B will supply new insight to
research for BNCT studies. Cancer detection and therapy will
be applicable in same schedule with 10B-18F-DG complex
e:
hulyaozdemir39@gmail.comSynthesis of borono-fluoro-deoxy-D-glucose as boron carrier for Boron Neutron Capture Therapy
(BNCT)
Hulya Ozdemir, Zafer Akan, Taner Ozel and Gokhan Oto
Van Yuzuncu Yil University, Turkey