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allied
academies
Asian Journal of Biomedical and Pharmaceutical Sciences | Volume 8
May 14-15, 2018 | Montreal, Canada
Global Summit on
Biopharma & Biotherapeutics
T
he discovery of the role nitric oxide (NO) in the various
pathophysiological and physiological processes leaded
to develop new drugs for modulation of the nitric oxide
(NO) production directly and/or indirectly, for therapeutic
purposes such as NO-releasing drugs, NO-inhibiting drugs,
and phosphodiesterase V inhibitors. There are numbers of
NO donor drugs showed an important therapeutic effect
in the treatment of many diseases such as arteriopathies,
various acute and chronic inflammatory conditions, and
several degenerative diseases (Alzheimer’s disease and
cancer). The NO donor anti-inflammatory drugs are a novel
class of compounds in which NO combined to an anti-
inflammatory agent to improve the efficacies and reduce
the side effects. They are combining the pharmacological
activities of anti-inflammatory and antinociceptive of drugs
with those of NO (vasodilator, anti-aggregant, anti-microbial
and immune modulator agent). In our pervious study, the
anti-inflammatory activity of different alkyl nitrate derivatives
of the various types of N-Aryl Piperamides (NAP) have been
screened and verified. In this study, we are investigating
the biological activity by targeting NF- B subunits and
Cyclooxygenase-2
in silico and in vitro
, and pharmacological
profiling along with toxicity predictions of various NAPs linked
via an ester bond to a spacer that is bound to a NO -releasing
moiety (-ONO2). The result in
silico
investigation indicated
that among 51 designed molecules, 3-((2E,4E) -5-(benzo [d]
[1,3] dioxol-5-yl) -N-(4-(hydroxymethyl) phenyl) Penta-2,4-
dienamido) propyl nitrate with code number PA-3’K showed
the best anti-inflammatory potential. These findings have
been tested and supported by the
in vitro
investigation and
will presenting along with.
e:
siavosh.farma@gmail.comImpact of novel N-aryl piperamide on NF- B translocation in neuro-inflammation: Rational drug
designing, synthesis, and biological evaluation
Sajad Shahbazi
1
, Shikha Singh
2
and Ranbir Chander Sobti
1, 3
1
Panjab University, India
2
Siksha O Anusandhan University, India
3
Babasaheb Bhimrao Ambedkar University, India