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Archives of Industrial Biotechnology | Volume 2
May 14-15, 2018 | Montreal, Canada
World Yeast Congress
S
accharomyces cerevisiae
has served as genetic model
organism for over a century, as a genomic powerhouse
since it was the first eukaryote to have its genome
sequenced in 1996, and more recently as a test-bed for the
development and application of chemogenomic assays.
Baker’s yeast has also provided fundamental insights into
evolutionary conserved biology as witnessed by three Nobel
prizes attributable to yeast- in cell-cycle biology, secretion
and autophagy. Its simplicity of cultivation, combined with
its functional conservation allows for the discovery of novel
chemical probes which can serve as tools to probe biological
function and new leads for drug discovery. In this talk, I
will describe how the HIHOP laboratory, established by
Guri Giaever, has deployed yeast-based assays to discover
novel-target-drug interactions, understand the mechanism
by which drug resistance develops and map the chemical-
genetic portrait of an organism.
e:
corey.nislow@ubc.caYeast as a test-bed for drug discovery: From target engagement to drug resistance
Corey Nislow
University of British Columbia, Canada