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Page 55
allied
academies
Archives of Industrial Biotechnology | Volume 2
May 14-15, 2018 | Montreal, Canada
World Yeast Congress
H
omologous to the vertebrate solute carrier SLC10A7, Rch1
is a novel regulator of
calcium homeostasis
in the plasma
membrane of the budding yeast
Saccharomyces cerevisiae
and the human yeast pathogen Candida albicans. ScRCH1
is a functional homolog of CaRCH1. ScRch1 and CaRch1
negatively regulate the calcium uptake in response to high
levels of extracellular calcium in
S. cerevisiae
and
C. albicans
,
respectively. However, CaRch1 is constitutively expressed,
while
ScRch1
is induced by a high level of calcium ions.
Transcriptional expression of ScRCH1 is positively regulated
by calcium/calcineurin signaling through the sole CDRE
element in its promoter. Furthermore, distribution of ScRch1
proteins in the plasma membrane changes in a dynamic
way, from multiple foci prior to cell division, accumulation
at the bud neck during bud growth, and dispersion along the
plasma membrane immediately prior to cytokinesis. Rch1 is
a novel member regulating calcium homeostasis in yeasts.
e:
linghuojiang@hotmail.comA novel plasma membrane regulator of
Calcium homeostasis
in yeasts
Linghuo Jiang
Shandong University of Technology School of Agricultural Engineering and Food Science, China