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allied
academies
Joint Event
February 21-22, 2019 | Paris, France
Microbiology & Applied
Microbiology
2
nd
International Conference on
World Congress on
Wound Care, Tissue Repair
and Regenerative Medicine
&
Journal of Trauma and Critical Care | Volume 3
Wound healing of oralmucositis by the use of preventive laser photobiomodulation in patients with
head and neck cancer undergoing radiochemotherapy
Alena Ribeiro Alves Peixoto Medrado
1
, Juliana Borges de Lima Dantas
2
, Gabriela Botelho Martins
3
, Manoela Carrera
4
and
Hayana Ramos
Lima
5
1
School of Medicine and Public Health, Brazil
2
Northeast Brazil College, Brazil
3
Health Sciences Institute of the Federal University of Bahia, Brazil
4
Federal University of Bahia, Brazil
5
Federal University of Southern Bahia, Brazil
Objective:
To evaluate the preventive effect of laser
photobiomodulation in the development of radio/
chemotherapy treatment inpatientswithhead andneck cancer.
Methods:
This randomized clinical study included patients
undergoing radiotherapy with or without associated
chemotherapy. The patients were allocated randomly to
the laser (LG, n = 30) and control (CG, n = 26) groups. The LG
(AsGaAl, 660 nm laser, 86.7 mW, 2 J/cm
2
) participated in the
preventive protocol, while the CG underwent a simulated
procedure without light emission (sham). The degree of oral
mucositis (OM), salivary flow and referred pain were evaluated
at the beginning of radiation therapy and during the 6th, 12th,
18th and 24th sessions.
Results:
Patients of both groups showed a significant increase
in the degree of OM, according to the progression of the
radiotherapy sessions (p < 0.01). Regarding OM, salivary flow,
and pain related to the oral cavity, there was no significant
difference between the groups in all periods assessed (p >
0.05). There was a significant reduction of salivary flow from
the 6th session when compared to the values from the start
of radiotherapy. The photobiomodulation laser did not affect
the experience of pain in patients during treatment (p < 0.001)
when compared to that during the start of treatment.
Conclusions:
The photobiomodulation laser protocol used
in this study was not effective in preventing OM radiation-
chemotherapy-induced OM in patients with head and neck
cancer.
Speaker Biography
Alena Ribeiro Alves Peixoto Medrado has completed her PhD at the age of 25 years
from Federal University of Bahia, BR. She is professor of Federal University of Bahia, BR.
Currently, working as assistant professor at Bahiana – School of Medicine and Public
Health, BR. She has over 200 publications that have been cited over 200 times and
her publication h-index is 20 and has been serving as an editorial board member of
reputed Journals.
e:
alenamedrado@hotmail.comAlena Ribeiro Alves Peixoto Medrado et al
.
, J Trauma Crit Care, Volume 3
DOI: 10.4066/2591-7358-C1-003