wound-care-microbiology-2019-posters-abstracts

Page 57

allied

academies

Joint Event

February 21-22, 2019 | Paris, France

Microbiology & Applied

Microbiology

International Conference on

World Congress on

Wound Care, Tissue Repair

and Regenerative Medicine

Journal of Trauma and Critical Care | Volume 3

Why Salmonella Dublin is a big deal?

Manal Mohammed

University of Westminster, UK

almonellosis is one of the most common foodborne

diseases worldwide that causes a huge burden of morbidity

and mortality in humans. Although non typhoidal Salmonella

serovars including Salmonella Dublin are associated primarily

with self-limiting gastrointestinal illness they have adapted

to cause invasive disease and systemic illness in humans

particularly children, elderly and immunocompromised

people.

Salmonella enterica

serovar Dublin is a zoonotic

infection that can be transmitted from cattle to humans

through consumption of contaminated milk and milk products.

Outbreaks of human infections by Salmonella Dublin have been

reported in several countries including high-income countries.

The genetic basis of virulence and invasiveness of Salmonella

Dublin is not well characterized. We apply next generation

sequencing and associated bioinformatics analyses tools is

characterize the invasome of Salmonella Dublin that enable

the bacteria to cause systemic illness in humans. We identified

several virulence factors that enable the bacteria to cause

invasive disease in humans however no genomic markers were

detected that differentiate among invasive and non-invasive

isolates suggesting that host factors and immune response play

a significant role in the disease outcome. There is no vaccine

against non-typhoidal Salmonella however our understanding

of the molecular basis of virulence in invasive Salmonella

Dublinwill provide insights into the development of an effective

vaccine through identification of novel virulence-attenuated

strains with a potential for use as vaccine candidates for high-

risk groups.

J Trauma Crit Care, Volume 3

DOI: 10.4066/2591-7358-C1-003