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academies
September 15-16, 2017 | Dallas, USA
International Conference on
VITAMINS, NUTRIGENOMICS & MALNUTRITION
Insights Nutr Metab 2017
Volume 1 Issue 1
F
unctionalization of therapeutic drug carriers with phenolic compounds
can potentially provide additional benefits in drug delivery for disease
treatment. Given that this modification determines final therapeutic
efficacy of drug carriers, we investigate the role of the grafting amount of
antioxidants onto
in situ
gelling copolymers for intracameral delivery of
pilocarpine in antiglaucoma treatment. As expected, increasing grafting of
thephenoliccompounds increasedtotalantioxidantactivitiesandfreeradical
scavenging abilities of synthesized carrier biomaterials. The hydrophilic
nature of antioxidant molecules strongly affected physicochemical
properties of carrier materials, thereby dictating
in vitro
release behaviors
and mechanisms of pilocarpine.
In vitro
oxidative stress challenges revealed
that biocompatible carriers with high antioxidant content alleviated lens
epithelial cell damage and reduced reactive oxygen species. Intraocular
pressure and pupil diameter in glaucomatous rabbits showed correlations
with antioxidant-mediated release of pilocarpine. Additionally, enhanced
pharmacological treatment effects prevented corneal endothelial cell loss
during disease progression. Increasing content of the phenolic compounds
increased total antioxidant level and decreased nitrite level in the aqueous
humor, suggesting a much improved antioxidant status in glaucomatous
eyes. This work significantly highlights the dependence of physicochemical
properties, drug release behaviors, and bioactivities on intrinsic antioxidant
capacities of therapeutic carrier biomaterials for glaucoma treatment.
Speaker Biography
Shih-Feng Chou is an Assistant Professor in the Department of Mechanical Engineering
at The University of Texas at Tyler. He completed his PhD from Auburn University in
2011 followed by working as a Research Associate at Dartmouth College from 2012
to 2013 and a senior fellow at University of Washington from 2014 to 2016. He has 21
publications that have been cited over 140 times, and his publication H-index is 6 and
has been serving as a reviewer of reputed journals.
e:
schou@uttyler.eduAntioxidant ability of phenolic compounds in drug delivery against glaucoma
Shih-Feng Chou
1
, Li-Jyuan Luo
2
and
Jui-Yang Lai
2
1
The University of Texas at Tyler, USA
2
Chang Gung University, Taiwan