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academies
September 15-16, 2017 | Dallas, USA
International Conference on
VITAMINS, NUTRIGENOMICS & MALNUTRITION
Insights Nutr Metab 2017
Volume 1 Issue 1
Background:
Type 2 diabetes mellitus (DM) is a chronic disease marked
by the elevation of blood glucose. There are many factors that can cause
type 2 DM, such as genetics, poor dietary habits, life style, and many more.
Choices of the correct food ingredients can help control blood glucose in
patients with type 2 DM.Jali (CoixLacrimaJobi L) is a tropical grain that
belongs to thePoaceaefamily or flowering plants (grass). In a study of twelve
antidiabetic plants, Jali has been demonstrated to have theantidiabetic
effects that can reduce blood glucose in patients with type 2 DM.8
Purpose:
To determine the effect of Jali extract on the mice’s blood glucose
with diabetes mellitus.
Methods:
An experimental studyhas been conducted in five groups of ten
male mice and eachhas beenadministratered with 10 mg of jali extract and
50 mg/kg in aquadest daily for 30 days. The groups are (1) negative control
(without aloxan and aqudest), (2) positive control (with injections of aloxan
and aquadest), (3) glibenclamide (GC)-50 standard (with injections of aloxan
and GC 50 mg/kg), (4) polysaccharide extract (BSF)-10 (induction of aloxan
and BSF 10 mg/kg), and (5) BSF-50 (induction of aloxan and BSF 50 mg/
kg). From each animal, serum blood glucose was recorded and analized
before the experiment started as the baseline, on the 15th, and 30th days,
these mice are then sacrificed by euthanasia on the 30th day. The results
demonstrated that jali has the effect of reducing mice’s serum blood glucose
in 30 days and it shows the efficacy of jali polysaccharide fraction as an
antidiabetic agent.
Results:
The use of jalipolysaccharide extract 50mg/kg body weight
significantly reduce blood glucose.
Conclusion:
The use of jali extract as a natural antidiabetic agent.
Effect of jali extract (
coixlacrimajobi l
) on the mice with diabetes mellitus’ blood glucose
in vivo
Nanny
1
, Kathena
2
, Ingrid
3
and
Yanti
4
Jaya Catholic University, Indonesia