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J Parasit Dis Diagn Ther 2017
Volume 2 Issue 3
Tropical Medicine 2017
Page 54
September 7-8, 2017 | Edinburgh, Scotland
4
th
International Conference on
Tropical Medicine, Infectious Diseases & Public Health
IS ARACHIDONIC ACID A NATURAL
SCHISTOSOMICIDE?
El Ridi R
a
, Hanna VS
a
, Gawish A
a
, Tallima H
a
and Abou El-Dahab M
b
a
Cairo University, Egypt
b
Ein Shams University, Egypt
S
chistosoma mansoni and S. haematobium infect >250
million people, yet not all people of the same community
and household. Regarding rodents, mice but not rats are
susceptible to infection with S. mansoni and hamsters but not
mice are entirely permissive to infection with S. haematobium.
A recent Brazilian publication has demonstrated that
resistance of the water-rat to S. mansoni infection might
be ascribed to stores of arachidonic acid (ARA) in liver.
We have previously shown that ARA is a safe and effective
schistosomicide in vitro, and in vivo in mice, hamsters and in
children. Schistosoma haematobium appeared more sensitive
than S. mansoni to We herein propose that ARA increased
levels might be predominantly responsible for natural attrition
of S. mansoni and S. haematobium in resistant experimental
rodents. Therefore, we compared and contrasted levels of
ARA in serum, lung and liver of mice (susceptible) and rats
(resistant) to S. mansoni at 1, 2, 3, 4 and 6 weeks after infection
with S. mansoni cercariae and between hamster (susceptible)
and mice (which are not permissive) at 1, 2, 3, 4, and 12 weeks
after infection with S. haematobium cercariae. Arachidonic
acid levels were assessed in serum by competetive enzyme-
linked immunosorbent assay, and in liver and lung sections
by immunohistochemistry and transmission electron
microscopy. We recorded highly significant, consistent and
reproducible correlation between ARA content in serum,
lung and liver and rodent resistance to schistosome infection,
thereby implicating ARA as a natural schistosomicide.
J Parasit Dis Diagn Ther 2017