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J Parasit Dis Diagn Ther 2017
Volume 2 Issue 3
Tropical Medicine 2017
Page 52
September 7-8, 2017 | Edinburgh, Scotland
4
th
International Conference on
Tropical Medicine, Infectious Diseases & Public Health
HUMAN IGG ANTIBODY RESPONSE TO
AEDESNTERM-34KDASALIVARYPEPTIDE,
AN EPIDEMIOLOGICAL TOOL TO ASSESS
VECTOR CONTROL IN CHIKUNGUNYA
AND DENGUE TRANSMISSIONAREA
E. Elanga-Ndille
a
, S. Doucoure
a
, A.Poinsignon
a
, F. Remoue
a
,
F. Mouchet
a
,
S. Cornelie
a
a
MIVEGEC Unit, France.
A
rboviral diseases are an important public health
concerns. Vector control remains the sole strategy to
fight against these diseases. Because of the important limits of
methods currently used to assess human exposure to Aedes
mosuito bites, much effort is being devoted to develop new
indicators. Recent studies have reported that human antibody
(Ab) responses to Aedes aegypti Nterm-34kDa salivary
peptide represent a promising biomarker tool to evaluate the
human-Aedes contact. The present study aims investigate
whether such biomarker could be used for assessing the
efficacy of vector control against Aedes.
Specific human IgG response to Nterm-34kDa peptide
was assessed from 102 individuals living in urban area of
Saint-Denis at La Reunion Island, Indian Ocean, before
and after the implementation of vector control against
Aedes mosquitoes. IgG response decreased after 2 weeks (P
< 0.0001), and remained low for 4 weeks post-intervention
(P = 0.0002). The specific IgG decrease was associated with
the decline of Aedes mosquito density, as estimated by
entomological parameters and closely correlated to vector
control implementation and was not associated with the use
of individual protection, daily commuting outside of the
house, sex and age. Our findings indicate a probable short-
term decrease of human exposure to Aedes bites just after
vector control implementation.
Results provided in the present study indicate that IgG Ab
response to Aedes aegypti Nterm-34kDa salivary peptide
could be a relevant short-time indicator for evaluating the
efficacy of vector control interventions against Aedes species.
J Parasit Dis Diagn Ther 2017