7 / 12
Page 54
allied
academies
J u l y 2 3 - 2 4 , 2 0 1 8 | R o m e , I t a l y
Note:
TRADITIONAL
MEDICINE AND ACUPUNCTURE
8
th
International Conference on
Journal of General Internal Medicine
|
ISSN: 2591-7951
|
Volume 2
Traditional 2018
Arch Gen Intern Med 2018, Volume 2 | DOI: 10.4066/2591-7951-C1-003
MAEKMOONDONG-TANG ATTENUATES LPS-INDUCED PULMONARY
FIBROSIS IN SMALL AIRWAY VIA TGF-Β, CCL-2 AND CXCL1
Soon-Young Lee
1
, Seung-Sik Cho
2
, Chun-Sik Bae
3
, Gye-Yeop Kim
1
and
Dae-Hun Park
1
1
Dongshin University, Korea
2
Mokpo National University, Korea
3
Chonnam National University, Korea
C
hronic obstructive pulmonary disease (COPD) is one of the top 10 death causes in the worldwide and especially the old
are more severe than the young. From Dongui Bogam a lot of prescriptions have been used for the respiratory disease and
Maekmoondong-tang is one of them. Maekmoondong-tang consists of several herbs such as
Glycyrrhizae radix, Oryza sativa,
Zizyphus jujube inermis, Ophiopogon japonicas, Pinellia ternate, Panax ginseng
, and so on. In this study the therapeutic effect of
Maekmoondong-tang against COPD was evaluated by the populations of WBCs and differential counts in BALF, IgE in serum,
histopathological changes in the lung such as inflammatory cell infiltration, fibrosis, etc., the changes of cytokine/chemokine
in the lung such as TGF-
β
, CCL-2, CXCL1 and CXCL11. In LPS-induced mouse model Maekmoondong-tang dose-dependently
attenuated thenumbersofWBCandneutrophil inBALF, IgE inserum, inflammatory cell infiltrationandfibrosis, cytokine/chemokine
in the lung Maekmoondong-tang effectively suppressed the typical changes-related with COPD such as the populations of WBC
and neutrophil in BALF, the level of IgE in serum, morphological changes (mucous hypersecretion, inflammatory cell infiltration,
alveolar wall destruction, and fibrosis), the DNA levels of cytokine/chemokine (
TGF-β, CCL-2, CXCL1, and CXCL11
) and the protein
expressions of cytokine/chemokine (
TGF-β, CCL-2, CXCL1, and CXCL11
) in the pulmonary system. One cytokine (TGF-
β
) and
two chemokine (CCL-2 and CXCL1) were significantly suppressed by 1500 mg/kg Maekmoondong-tang treatment compared
to Spiriva treatment. From the results we concluded that Maekmoondong-tang should be the effective traditional prescription.
atiqhassan@gmail.com