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J u l y 2 3 - 2 4 , 2 0 1 8 | R o m e , I t a l y
Note:
TRADITIONAL
MEDICINE AND ACUPUNCTURE
8
th
International Conference on
Journal of General Internal Medicine
|
ISSN: 2591-7951
|
Volume 2
Traditional 2018
Arch Gen Intern Med 2018, Volume 2 | DOI: 10.4066/2591-7951-C1-003
LYCIUM CHINENSE
MILL IMPROVES HYPOGONADISM VIA ANTI-
OXIDATIVE STRESS AND ANTI-APOPTOTIC EFFECT IN OLD AGED RAT
MODEL
Woong Jin Bae
The Catholic University of Korea, Korea
T
o evaluate the pharmacological effects of goji berry (
Lycium chinense
Mill) in an animal model of late onset hypogonadism
(LOH). 18-month-old 30 male Sprague-Dawley (SD) rats were used as the LOH aged rat model. Rats were divided into five
groups: a control group (n=6), low concentration goji berry extract group (150 mg/kg/day) (n=6), high concentration goji berry
extract group (300 mg/kg/day) (n=6), low concentration goji berry complex extract group (150mg/kg/day) (n=6), and high goji
berry complex concentration extract group (300 mg/kg/day) (n=6). After six weeks of treatment, sperm counts and motility, serum
testosterone level, androgen receptor (AR) expression, oxidative stress marker, and apoptotic factors were examined. Goji berry
extracts increased testosterone level to 2.07±0.06 p mol/L in the goji berry 150mg/kg group, 2.39±0.08 pmol/L in the goji berry 300
mg/kg group, 2.97±0.03 pmol/L in the goji berry complex 150 mg/kg group, and 3.34±0.04 pmol/L in the goji berry complex 300
mg/kg group compared to 1.86±0.03 pmol/L in the control group, respectively (p<0.05). AR expressions were increased in testis
tissue significantly but were not significant in prostate tissue. Goji berry might improve LOH by reversing testicular dysfunction via
an anti-oxidative stress mechanism without inducing prostate disease.
bwoong@catholic.ac.kr