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J Clin Exp Tox 2017 | Volume 1 | Issue 2
Toxicology and Pharmacology
November 01-02, 2017 | Toronto, Canada
International Conference on
In vitro
assessment of the toxic effects of an AKWATON based-disinfectant on human tissues
Mathias Oulé
Université de Saint-Boniface, Canada
T
he purpose of this study is to prove the potential safe use
of AKWATONas anewantimicrobial product.Many service
products are often removed from the market due to their
toxic effects on the human body or to their aggressiveness
towards the environment. Antimicrobial products such
as disinfectants may contain harmful ingredients that can
cause disease. Some disinfecting products are corrosive or
irritating; others produce strong odors, which in the long
run can cause real health problems. AKWATON is a new
disinfectant, member of the family of guanidine polymers. Its
bactericidal, fungicidal and sporicidal properties have been
demonstrated andwidely documented. In this study, the toxic
effects of AKWATON and of three well known commercial
antimicrobial products currently on market, were evaluated
and compared on various human tissues including eyes,
lung, skin and liver cells. The testing were performed using
the TB (Trypan blue) and MTT (3-(4, 5-Dimethylthiazol-2-
yl)-2, 5-diphenyltetrazolium bromide) methods. Cell-cultures
and the different tests done, showed that the AKWATON
based-disinfectant was much less toxic, killing many fewer
cells than the commercial disinfectants. It spared more than
64% of skin cells; 65% of lung (IMR-90) cells; 66% of eye cells
(ARPE-19) and 64% of liver (Hep-G2) cells while some well-
known disinfectants currently marketed killed 100% of cells.
This study demonstrated that AKWATON can be used as an
odorless, colorless, non-corrosive and harmless disinfectant
for hospital, agriculture industry, farming, food service and
household facilities or as antiseptic.
Speaker Biography
Mathias Oulé holds a Bachelor’s degree in Mathematics, a Master’s degree in
Biochemistry from the University of Abidjan (Côte d’Ivoire), a Master’s degree in
Microbiology and a Doctorate in Microbiology from Laval University (Québec). Since
2000, he is Professor of Microbiology at Saint-Boniface University (Winnipeg, MB);
Head of the Department of Biological Sciences from 2006 to 2010. For several years,
he has been researching on AKWATON, a microbicidal polymer with high solubility in
water, odorless, colorless, non-corrosive and harmless, to fight nosocomial infections
and superbugs. In 2012, the Society for General Microbiology (SGM) issued press
release on his studies on AKWATON’s sporicidal activity, published in the
Journal of
Medical Microbiology
(JMM).
e:
MOule@ustboniface.ca