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J Clin Exp Tox 2017 | Volume 1 | Issue 2

Toxicology and Pharmacology

November 01-02, 2017 | Toronto, Canada

International Conference on

enign prostate hyperplasia (BPH) is a urological disorder

caused by the noncancerous enlargement of the prostate

as men age. As the prostate enlarges, it can constrict the

urethra, inducing various symptoms including a weak urinary

stream, incomplete bladder emptying, nocturia, dysuria and

bladder outlet obstruction. Conventionally used drugs like

5 α -reductase inhibitors and α adrenoceptors antagonists

are used to treat benign prostatic hyperplasia, but they

possess various side effects like impotence, decreased

libido, ejaculation disorder, gynaecomastia, dizziness, upper

respiratory tract infection, headache, fatigue and chest pain,

also it was found in our previous study combination of fatty

acid like lauric and myristic acid can be used for treatments

of benign prostatic hyperplasia with minimum side effects

so present study undertaken to compare side effects of

conventionally used drugs and fatty acid, and hence so

present study investigated to compare toxicological potential

of combined therapy with doses of finasteride and alfuzosin

to lauric and myristic acid orally administered for 28 days to

male Sprague Dawley rats. Male animals were randomized

into three groups of six animals each one: a control group

treated only with the vehicle and two groups treated with

combination of, Finasteride (50 mg/kg)+Alfuzosin (50 mg/

kg) {FA}, and Lauric acid (180 mg/kg) + myristic acid (70 mg/

kg) {LA}, respectively. The variables analyzed were done like

mortality, clinical signs, body weight, food consumption,

hematology and blood parameters, relative organ weight

and histopathological findings. Treatment with FA and LA

combined therapy significantly reduced the relative organ

weight of sex organs in animals treated. In conclusion, the

combined therapy orally administered to male rats did

not induce toxicological effects except the atrophy of the

accessory sex organs related to FA administration, weight

gain in fatty acid treatment groups so results show both

combinations are relatively safe for the treatments of benign

prostatic hyperplasia.

Comparative toxicological evaluation of the combined therapy of finasteride and alfuzosin to lauric acid

and myristic acid in male rats

Anup A Patil

Krishna Institute of Medical Sciences Deemed University, India