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J Clin Exp Tox 2017 | Volume 1 | Issue 2
Toxicology and Pharmacology
November 01-02, 2017 | Toronto, Canada
International Conference on
A
number of processes are thought to contribute to the
development of epilepsy including increased excitatory
synaptic transmission, neuronal cell death and development
of aberrant innervations pattern in part arising from axonal
growth. Recent findings indicate that adhesion molecules
and their receptors play an important role in these processes
and contribute significantly in epileptogenesis. Among the
adhesion molecules, cell surface glycoproteins CD44 and
CD90 are reported to be up-regulated after neuronal injury
or epilepsy. Focus of this study was to evaluate the effect
of classical anticonvulsants i.e., diazepam and phenytoin and
an essential oil of
Allium cepa
AC-31B on the expression of
these markers in the PTZ-induced model of epilepsy. Here
we tested the hypothesis that anticonvulsant therapy that
can reduce the level of CD44/CD90 expression
in vivo
model
of epileptogenesis can be used to control the underlying
process of epileptogenesis. Targeting CD44/CD90 might be
a novel therapeutic target in neurological disorders. Mice
weighing 20-25 gm were subjected to PTZ-induced kindling
and their seizure-related behaviors were monitored. Once
stage 4 seizures were prominent, animals were sacrificed and
the brain samples were collected for the determination of
CD44/CD90 expression. The results revealed that AC-31B not
only halts the development of epileptogenesis in PTZ-kindled
mice but also significantly reduced the expression of CD44/
CD90. Based on these observations, we suggest that AC-31B
can be effectively used to control the underlying pathology
of epileptogenesis. This finding uncovers a potential effect
of AC-31B in epileptogenesis and may provide a new
therapeutic target that can be harnessed for the prevention
of epilepsy development or progression.
e
:shabana.simjee@iccs.eduNature’s own remedies:
Allium cepa
- does it offer new options for the treatment of epilepsy?
Shabana Usman Simjee
1, 2
and Humera Perveen
1
, Uzair Nisar
1
, Maha Shahid
1
and
Marium Askani
1
1
H E J Research Institute of Chemistry, Pakistan
2
University of Karachi, Pakistan