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J Clin Exp Tox 2017 | Volume 1 | Issue 2
Toxicology and Pharmacology
November 01-02, 2017 | Toronto, Canada
International Conference on
Objective: To investigate the effect of Yi Shen Pin Gan Fang-a
Chinese Herb Formula in treating the Ultra High Risk for
Psychosis population compared with aripiprazole.
Method: 54 Ultra High Risk for Psychosis population,
matched for age, gender, handedness and education, were
randomly assigned to receive either Yi Shen Pin Gan Fang and
aripiprazole placebo or aripiprazole (5–10 mg/day) and Yi
Shen Pin Gan Fang placebo for a 12-week period. At baseline,
4th week, 8th week, 12th week, clinical effect was evaluated
with the Structured Interview for Prodromal Syndromes
(SIPS), Positive and Negative Syndrome Scale (PANSS) and
the Global Assessment of Functioning Scale (GAF), side effect
was measured by Udvalg for Kliniske Undersogelser (UKU).
Neurocognitive function was assessed at baseline and 12th
week.
Result: For GAF, PANSS and SIPS, there was no difference
between two groups (F=0.04, 0.05, 0.15, P>0.05), there was
significant improvement since 4th week till 12th week in each
group compared with baseline (F=27.16 59.91, 55.92, 0.05,
0.15, P<0.001). Compared with baseline, for the Trail Making
test, there is no difference between and intra groups (P>0.05);
In Chinese Medicine Treatment group, Verbal Learning test,
Visual Memory test, CPT and Stroop-(colour/word) test were
significant improved (P<0.05); For Aripiprazole Treatment
group, only Verbal Learning test, Stroop-word test were
significant improved (P<0.05). No obvious side effects were
found in Yi Shen Pin Gan Fang treatment group.
Conclusion: Yi Shen Pin Gan Fang was effective in treating
Ultra High Risk for Psychosis population.
e:
Yi Shen Pin Gan Fang-a Chinese herb formula is effective in treating the ultra-high risk for psychosis
population
Jia Hong-Xiao, Feng Xiujie, Zhu Hong and Liu Shan-Shan
Capital Medical University, China